(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1. 0] hexyl-3-benzyl)-2-cyclohexyl-2-hydroxy-2-phenyl acetamide

Base Information

Chemical Name:(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1. 0] hexyl-3-benzyl)-2-cyclohexyl-2-hydroxy-2-phenyl acetamide
CAS No.:712355-73-2
Molecular Formula:C₂₆H₃₂N₂O₂
Molecular Weight:404.552
Hs Code.:

Synonyms:(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1. 0] hexyl-3-benzyl)-2-cyclohexyl-2-hydroxy-2-phenyl acetamide

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Chemical Property of (1α, 5α, 6α)-6-N-(3-azabicyclo [3.1. 0] hexyl-3-benzyl)-2-cyclohexyl-2-hydroxy-2-phenyl acetamide

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Technology Process of (1α, 5α, 6α)-6-N-(3-azabicyclo [3.1. 0] hexyl-3-benzyl)-2-cyclohexyl-2-hydroxy-2-phenyl acetamide

There total 6 articles about (1α, 5α, 6α)-6-N-(3-azabicyclo [3.1. 0] hexyl-3-benzyl)-2-cyclohexyl-2-hydroxy-2-phenyl acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 931-50-0
cyclohexylmagnesium bromide

: 712355-73-2
(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1. 0] hexyl-3-benzyl)-2-cyclohexyl-2-hydroxy-2-phenyl acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0 - 20 °C

2: KOH / methanol / 20 °C

3: 1-hydroxybenzotriazole; N-methylmorpholine; N-ethyl-N'-(3-dimethylaminopropyl)-N'-ethylcarbodiimide*HCl / dimethylformamide

With 4-methyl-morpholine; potassium hydroxide; benzotriazol-1-ol; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.06.081

Reference yield:

: 76-93-7
Benzilic acid

: 151860-17-2
(1α,5α,6α)-3-N-benzyl-6-amino-3-aza-bicyclo[3.1.0]hexane

: 712355-73-2
(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1. 0] hexyl-3-benzyl)-2-cyclohexyl-2-hydroxy-2-phenyl acetamide

Guidance literature:: Benzilic acid; (1α,5α,6α)-3-N-benzyl-6-amino-3-aza-bicyclo[3.1.0]hexane; With 4-methyl-morpholine; benzotriazol-1-ol; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.5h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 0 ℃; for 1h;

at 0 - 25 ℃; for 13h;

Reference yield:

: 1603-79-8
phenylglyoxylic acid ethyl ester

: 712355-73-2
(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1. 0] hexyl-3-benzyl)-2-cyclohexyl-2-hydroxy-2-phenyl acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0 - 20 °C

2: KOH / methanol / 20 °C

3: 1-hydroxybenzotriazole; N-methylmorpholine; N-ethyl-N'-(3-dimethylaminopropyl)-N'-ethylcarbodiimide*HCl / dimethylformamide

With 4-methyl-morpholine; potassium hydroxide; benzotriazol-1-ol; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.06.081