(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] cyclohexyl)-2-hydroxy-2-cyclohexyl-2-phenyl acetamide

Base Information

Chemical Name:(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] cyclohexyl)-2-hydroxy-2-cyclohexyl-2-phenyl acetamide
CAS No.:712356-35-9
Molecular Formula:C₁₉H₂₆N₂O₂
Molecular Weight:314.428
Hs Code.:

Synonyms:(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] cyclohexyl)-2-hydroxy-2-cyclohexyl-2-phenyl acetamide

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Chemical Property of (1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] cyclohexyl)-2-hydroxy-2-cyclohexyl-2-phenyl acetamide

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Technology Process of (1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] cyclohexyl)-2-hydroxy-2-cyclohexyl-2-phenyl acetamide

There total 5 articles about (1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] cyclohexyl)-2-hydroxy-2-cyclohexyl-2-phenyl acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 712355-73-2
(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1. 0] hexyl-3-benzyl)-2-cyclohexyl-2-hydroxy-2-phenyl acetamide

: 712356-35-9
(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] cyclohexyl)-2-hydroxy-2-cyclohexyl-2-phenyl acetamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol;

Reference yield:

: 931-50-0
cyclohexylmagnesium bromide

: 712356-35-9
(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] cyclohexyl)-2-hydroxy-2-cyclohexyl-2-phenyl acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0 - 20 °C

2: KOH / methanol / 20 °C

3: 1-hydroxybenzotriazole; N-methylmorpholine; N-ethyl-N'-(3-dimethylaminopropyl)-N'-ethylcarbodiimide*HCl / dimethylformamide

4: H₂ / Pd/C / methanol / 3 h / 20 °C / 2327.23 Torr

With 4-methyl-morpholine; potassium hydroxide; hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.06.081

Reference yield:

: 1603-79-8
phenylglyoxylic acid ethyl ester

: 712356-35-9
(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] cyclohexyl)-2-hydroxy-2-cyclohexyl-2-phenyl acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0 - 20 °C

2: KOH / methanol / 20 °C

3: 1-hydroxybenzotriazole; N-methylmorpholine; N-ethyl-N'-(3-dimethylaminopropyl)-N'-ethylcarbodiimide*HCl / dimethylformamide

4: H₂ / Pd/C / methanol / 3 h / 20 °C / 2327.23 Torr

With 4-methyl-morpholine; potassium hydroxide; hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.06.081