N-(2S)-2-[(tert-butoxycarbonylamino)-3-(4-methoxyphenyl)propyl]acetamide

Base Information

Chemical Name:N-(2S)-2-[(tert-butoxycarbonylamino)-3-(4-methoxyphenyl)propyl]acetamide
CAS No.:443150-01-4
Molecular Formula:C₁₇H₂₆N₂O₄
Molecular Weight:322.404
Hs Code.:

Synonyms:N-(2S)-2-[(tert-butoxycarbonylamino)-3-(4-methoxyphenyl)propyl]acetamide

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Chemical Property of N-(2S)-2-[(tert-butoxycarbonylamino)-3-(4-methoxyphenyl)propyl]acetamide

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Technology Process of N-(2S)-2-[(tert-butoxycarbonylamino)-3-(4-methoxyphenyl)propyl]acetamide

There total 3 articles about N-(2S)-2-[(tert-butoxycarbonylamino)-3-(4-methoxyphenyl)propyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 108-24-7
acetic anhydride

: 443149-91-5
N-[(1S)-2-azido-1-(4-methoxyphenylmethyl)ethyl](tert-butoxy)carboxamide

: 443150-01-4
N-(2S)-2-[(tert-butoxycarbonylamino)-3-(4-methoxyphenyl)propyl]acetamide

Guidance literature:: With hydrogen; 10percent Pd/C; at 20 ℃; for 5h; under 760.051 Torr;
DOI:10.1021/jo0110698

Reference yield:

: 126395-29-7
[(S)-2-hydroxy-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester

: 443150-01-4
N-(2S)-2-[(tert-butoxycarbonylamino)-3-(4-methoxyphenyl)propyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

2: 1.64 g / NaN₃ / dimethylformamide / 4 h / 60 °C

3: 74 percent / H₂ / 10percent Pd/C / 5 h / 20 °C / 760.05 Torr

With sodium azide; hydrogen; triethylamine; 10percent Pd/C; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0110698

Reference yield:

: 153923-41-2
(S)-2-[ (tert-butoxycarbonyl)-amino]-3-(4-methoxyphenyl)-propylmethanesulfonate

: 443150-01-4
N-(2S)-2-[(tert-butoxycarbonylamino)-3-(4-methoxyphenyl)propyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.64 g / NaN₃ / dimethylformamide / 4 h / 60 °C

2: 74 percent / H₂ / 10percent Pd/C / 5 h / 20 °C / 760.05 Torr

With sodium azide; hydrogen; 10percent Pd/C; In N,N-dimethyl-formamide;
DOI:10.1021/jo0110698