2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid

Base Information

• Chemical Name: 2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
• CAS No.: 72678-93-4
• Molecular Formula: C₁₁H₁₃NO₄S
• Molecular Weight: 255.295
• Mol file: 72678-93-4.mol

Synonyms:(2RS,4R)-2-(2-hydroxy-3-methoxy-phenyl)-thiazolidine-4-carboxylic acid

Chemical Property of 2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid

Chemical Property:

• Water Solubility.: 1.532g/L(2.1 oC)

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid

There total 1 articles about 2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

l-cysteine hydrochloride (52-89-1) + 3-methoxy-2-hydroxybenzaldehyde (148-53-8) → (2RS,4R)-2-(2-hydroxy-3-methoxy-phenyl)-thiazolidine-4-carboxylic acid (72678-93-4,1212457-37-8)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; water; for 6h;

DOI:10.1016/j.bmc.2011.02.019

Reference yield: 88.9%

(2RS,4R)-2-(2-hydroxy-3-methoxy-phenyl)-thiazolidine-4-carboxylic acid (72678-93-4,1212457-37-8) + phenylacetyl chloride (103-80-0) → 3-phenylacetyl-(2RS,4R)-2-(2-hydroxy-3-methoxy-phenyl)-thiazolidine-4-carboxylic acid (1297309-37-5)

Guidance literature:

(2RS,4R)-2-(2-hydroxy-3-methoxy-phenyl)-thiazolidine-4-carboxylic acid; phenylacetyl chloride; With sodium hydrogencarbonate; In water; at 20 ℃;

With citric acid; In water; pH=2 - 3;

DOI:10.1016/j.bmc.2011.02.019

Reference yield: 70.5%

(2RS,4R)-2-(2-hydroxy-3-methoxy-phenyl)-thiazolidine-4-carboxylic acid (72678-93-4,1212457-37-8) + chloroacetyl chloride (79-04-9) → 3-(2-chloro-acetyl)-(2RS,4R)-2-(2-hydroxy-3-methoxyphenyl)-thiazolidine-4-carboxylic acid (1297309-30-8)

Guidance literature:

(2RS,4R)-2-(2-hydroxy-3-methoxy-phenyl)-thiazolidine-4-carboxylic acid; chloroacetyl chloride; With sodium hydrogencarbonate; In water; at 20 ℃;

With citric acid; In water; pH=2 - 3;

DOI:10.1016/j.bmc.2011.02.019

upstream raw materials:

l-cysteine hydrochloride

3-methoxy-2-hydroxybenzaldehyde

Downstream raw materials:

(R)-3-(3-Benzoylsulfanyl-propionyl)-2-(2-hydroxy-3-methoxy-phenyl)-thiazolidine-4-carboxylic acid

(R)-2-(2-Hydroxy-3-methoxy-phenyl)-3-(3-mercapto-propionyl)-thiazolidine-4-carboxylic acid

3-(2-chloro-acetyl)-(2RS,4R)-2-(2-hydroxy-3-methoxyphenyl)-thiazolidine-4-carboxylic acid

3-phenylacetyl-(2RS,4R)-2-(2-hydroxy-3-methoxy-phenyl)-thiazolidine-4-carboxylic acid