(1R,3S)-6,8-bis(benzyloxy)-1-methyl-3-(((triisopropylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(1R,3S)-6,8-bis(benzyloxy)-1-methyl-3-(((triisopropylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:1248682-27-0
Molecular Formula:C₃₄H₄₇NO₃Si
Molecular Weight:545.838
Hs Code.:

Synonyms:(1R,3S)-6,8-bis(benzyloxy)-1-methyl-3-(((triisopropylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (1R,3S)-6,8-bis(benzyloxy)-1-methyl-3-(((triisopropylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (1R,3S)-6,8-bis(benzyloxy)-1-methyl-3-(((triisopropylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline

There total 3 articles about (1R,3S)-6,8-bis(benzyloxy)-1-methyl-3-(((triisopropylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1248682-22-5
(S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline

: 676-58-4
methylmagnesium chloride

: 1248682-27-0
(1R,3S)-6,8-bis(benzyloxy)-1-methyl-3-(((triisopropylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: (S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline; methylmagnesium chloride; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at 20 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja1065202

Reference yield:

: 1248682-22-5
(S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline

: 917-54-4
methyllithium

: 1248682-27-0
(1R,3S)-6,8-bis(benzyloxy)-1-methyl-3-(((triisopropylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline

: 1248682-39-4
(1S,3S)-6,8-bis(benzyloxy)-1-methyl-3-(((triisopropylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: In tetrahydrofuran; at -78 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja1065202

Reference yield:

: 1248682-22-5
(S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline

: 676-58-4
methylmagnesium chloride

: 1248682-27-0
(1R,3S)-6,8-bis(benzyloxy)-1-methyl-3-(((triisopropylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline

: 1248682-39-4
(1S,3S)-6,8-bis(benzyloxy)-1-methyl-3-(((triisopropylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: In tetrahydrofuran; at -78 - 20 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja1065202