(S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline

Base Information

Chemical Name:(S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline
CAS No.:1248682-22-5
Molecular Formula:C₃₃H₄₃NO₃Si
Molecular Weight:529.795
Hs Code.:

Synonyms:(S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline

Suppliers and Price of (S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline

Chemical Property:

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Technology Process of (S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline

There total 1 articles about (S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1248682-18-9
(S)-N-(1-(3,5-bis(benzyloxy)phenyl)-3-((triisopropylsilyl)oxy)propan-2-yl)formamide

: 1248682-22-5
(S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline

Guidance literature:: With 2-Methylpyrazine; trichlorophosphate; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ja1065202

Reference yield: 85.0%

: 1248682-22-5
(S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline

: 676-58-4
methylmagnesium chloride

: 1248682-27-0
(1R,3S)-6,8-bis(benzyloxy)-1-methyl-3-(((triisopropylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: (S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline; methylmagnesium chloride; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at 20 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja1065202

Reference yield:

: 1248682-22-5
(S)-6,8-bis(benzyloxy)-3-(((triisopropylsilyl)oxy)methyl)-3,4-dihydroisoquinoline

: 917-54-4
methyllithium

: 1248682-27-0
(1R,3S)-6,8-bis(benzyloxy)-1-methyl-3-(((triisopropylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline

: 1248682-39-4
(1S,3S)-6,8-bis(benzyloxy)-1-methyl-3-(((triisopropylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: In tetrahydrofuran; at -78 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja1065202