Ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

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Chemical Name:Ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate
CAS No.:1204423-91-5
Molecular Formula:C₂₄H₂₉N₃O₅
Molecular Weight:439.511
Hs Code.:

Synonyms:Ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

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Chemical Property of Ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

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Technology Process of Ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

There total 14 articles about Ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1204423-92-6
C₂₄H₂₇N₃O₅

: 1204423-91-5
Ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

Guidance literature:: With hydrogen; 20% palladium(II) hydroxide on carbon; In tetrahydrofuran; ethanol; at 20 ℃; for 2h;

Reference yield:

: 3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9
p-methoxyl benzaldoxime

: 1204423-91-5
Ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 2 h / 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / Cooling with ice

4.1: potassium carbonate / acetonitrile / 20 °C

5.1: sodium hydroxide; water / tetrahydrofuran / 72 h / 20 °C

5.2: 6.5 h / 120 °C

6.1: tetrahydrofuran; methanol / 48 h / 20 °C

7.1: N-Bromosuccinimide; acetic acid / 4 h / 70 °C

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

10.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 110 °C

11.1: hydrogen / 20% palladium(II) hydroxide on carbon / ethanol; tetrahydrofuran / 2 h / 20 °C

With N-chloro-succinimide; N-Bromosuccinimide; carbon tetrabromide; water; hydrogen; sodium carbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% palladium(II) hydroxide on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 38435-51-7
N-hydroxy-4-methoxy-benzenecarboximidoyl chloride

: 1204423-91-5
Ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine / dichloromethane / 2 h / 20 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / Cooling with ice

3.1: potassium carbonate / acetonitrile / 20 °C

4.1: sodium hydroxide; water / tetrahydrofuran / 72 h / 20 °C

4.2: 6.5 h / 120 °C

5.1: tetrahydrofuran; methanol / 48 h / 20 °C

6.1: N-Bromosuccinimide; acetic acid / 4 h / 70 °C

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 110 °C

10.1: hydrogen / 20% palladium(II) hydroxide on carbon / ethanol; tetrahydrofuran / 2 h / 20 °C

With N-Bromosuccinimide; carbon tetrabromide; water; hydrogen; sodium carbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% palladium(II) hydroxide on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;