ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

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Chemical Name:ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate
CAS No.:1204423-93-7
Molecular Formula:C₂₂H₂₅N₃O₅
Molecular Weight:411.458
Hs Code.:

Synonyms:ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

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Chemical Property of ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

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Technology Process of ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

There total 15 articles about ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1204423-91-5
Ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

: 1204423-93-7
ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

Guidance literature:: Ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; ethanol; at 85 ℃; for 7h;

With hydrogenchloride; In tetrahydrofuran; ethanol; water;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1204423-93-7
ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 13 steps

1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 1 h / 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Cooling with ice

3.1: triethylamine / dichloromethane / 2 h / 20 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / Cooling with ice

5.1: potassium carbonate / acetonitrile / 20 °C

6.1: sodium hydroxide; water / tetrahydrofuran / 72 h / 20 °C

6.2: 6.5 h / 120 °C

7.1: tetrahydrofuran; methanol / 48 h / 20 °C

8.1: N-Bromosuccinimide; acetic acid / 4 h / 70 °C

9.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

10.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

11.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 110 °C

12.1: hydrogen / 20% palladium(II) hydroxide on carbon / ethanol; tetrahydrofuran / 2 h / 20 °C

13.1: water; lithium hydroxide / ethanol; tetrahydrofuran / 7 h / 85 °C

With N-chloro-succinimide; N-Bromosuccinimide; carbon tetrabromide; hydroxylamine hydrochloride; water; hydrogen; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% palladium(II) hydroxide on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9
p-methoxyl benzaldoxime

: 1204423-93-7
ethyl 4-{3-[4-ethyl-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 12 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 2 h / 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / Cooling with ice

4.1: potassium carbonate / acetonitrile / 20 °C

5.1: sodium hydroxide; water / tetrahydrofuran / 72 h / 20 °C

5.2: 6.5 h / 120 °C

6.1: tetrahydrofuran; methanol / 48 h / 20 °C

7.1: N-Bromosuccinimide; acetic acid / 4 h / 70 °C

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

10.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 110 °C

11.1: hydrogen / 20% palladium(II) hydroxide on carbon / ethanol; tetrahydrofuran / 2 h / 20 °C

12.1: water; lithium hydroxide / ethanol; tetrahydrofuran / 7 h / 85 °C

With N-chloro-succinimide; N-Bromosuccinimide; carbon tetrabromide; water; hydrogen; sodium carbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% palladium(II) hydroxide on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;