3-bromo-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

Base Information

• Chemical Name: 3-bromo-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine
• CAS No.: 1610928-02-3
• Molecular Formula: C₂₁H₂₂BrF₃N₂O₄
• Molecular Weight: 503.316

Synonyms:3-bromo-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

Chemical Property of 3-bromo-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

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Technology Process of 3-bromo-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

There total 3 articles about 3-bromo-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine (1610927-94-0) → 3-bromo-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine (1610928-02-3)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 1h;

DOI:10.1039/c4tc00234b

Reference yield:

2-amino-5-trifluoromethylpyridine (74784-70-6) → 3-bromo-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine (1610928-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iodine / neat (no solvent) / 19 h / 100 °C

1.2: 1.5 h / Reflux

2.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

With N-Bromosuccinimide; iodine; In acetonitrile;

DOI:10.1039/c4tc00234b

Reference yield:

1-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)ethanone → 3-bromo-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine (1610928-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iodine / neat (no solvent) / 19 h / 100 °C

1.2: 1.5 h / Reflux

2.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

With N-Bromosuccinimide; iodine; In acetonitrile;

DOI:10.1039/c4tc00234b

upstream raw materials:

2-amino-5-trifluoromethylpyridine

2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

Downstream raw materials:

4-(2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-2-methylbut-3-yn-2-ol

2,5-bis((2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)ethynyl)pyrazine

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