4-chloro-1-(5-fluoro-2-methyl-phenyl)-3-trimethylsilyloxy-2-aza-1,3-butadiene

Base Information

Chemical Name:4-chloro-1-(5-fluoro-2-methyl-phenyl)-3-trimethylsilyloxy-2-aza-1,3-butadiene
CAS No.:1240310-54-6
Molecular Formula:C₁₃H₁₇ClFNOSi
Molecular Weight:285.821
Hs Code.:

Synonyms:4-chloro-1-(5-fluoro-2-methyl-phenyl)-3-trimethylsilyloxy-2-aza-1,3-butadiene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-chloro-1-(5-fluoro-2-methyl-phenyl)-3-trimethylsilyloxy-2-aza-1,3-butadiene

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Technology Process of 4-chloro-1-(5-fluoro-2-methyl-phenyl)-3-trimethylsilyloxy-2-aza-1,3-butadiene

There total 1 articles about 4-chloro-1-(5-fluoro-2-methyl-phenyl)-3-trimethylsilyloxy-2-aza-1,3-butadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-77-4
chloro-trimethyl-silane

: 22062-53-9
5-fluoro-2-methylbenzaldehyde

: 79-04-9
chloroacetyl chloride

: 1240310-54-6
4-chloro-1-(5-fluoro-2-methyl-phenyl)-3-trimethylsilyloxy-2-aza-1,3-butadiene

Guidance literature:: 5-fluoro-2-methylbenzaldehyde; With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; Inert atmosphere;

chloroacetyl chloride; With triethylamine; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 949026-52-2
E/Z-6-chloro-3-(3-chloro-benzylidene)-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

: 1240310-54-6
4-chloro-1-(5-fluoro-2-methyl-phenyl)-3-trimethylsilyloxy-2-aza-1,3-butadiene

: racemic (2'R,3R,4'S,5'S)-5',6-dichloro-4'-(3-chloro-phenyl)-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Guidance literature:: E/Z-6-chloro-3-(3-chloro-benzylidene)-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester; 4-chloro-1-(5-fluoro-2-methyl-phenyl)-3-trimethylsilyloxy-2-aza-1,3-butadiene; In toluene; at 145 ℃; for 0.75h; Sealed tube; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;