(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-8-fluoro-2-methoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Base Information

• Chemical Name: (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-8-fluoro-2-methoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol
• CAS No.: 1599530-96-7
• Molecular Formula: C₃₁H₂₃ClF₄N₆O₂
• Molecular Weight: 623.009
• Mol file: 1599530-96-7.mol

Synonyms:(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-8-fluoro-2-methoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Chemical Property of (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-8-fluoro-2-methoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-8-fluoro-2-methoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

There total 7 articles about (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-8-fluoro-2-methoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone (1599524-55-6) + 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloro-8-fluoroquinoline (1599529-36-8) + sodium methylate (124-41-4) → (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-8-fluoro-2-methoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol (1599530-96-7)

Guidance literature:

3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloro-8-fluoroquinoline; sodium methylate; In toluene; at 108 - 110 ℃; for 12h; Sealed tube;

(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone; In tetrahydrofuran; at -78 - 0 ℃; for 0.866667h;

With water; ammonium chloride; In tetrahydrofuran; at 20 ℃;

Reference yield:

6-trifluoromethylnicotinic acid (231291-22-8) → (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-8-fluoro-2-methoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol (1599530-96-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 7 - 20 °C

3.1: TurboGrignard / tetrahydrofuran / 1 h / 16.6 - 25 °C

3.2: 20 h / 5.3 - 20 °C

4.1: toluene / 12 h / 108 - 110 °C / Sealed tube

4.2: 0.87 h / -78 - 0 °C

4.3: 20 °C

With TurboGrignard; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

6-(trifluoromethyl)nicotinoyl chloride (358780-13-9) → (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-8-fluoro-2-methoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol (1599530-96-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 7 - 20 °C

2.1: TurboGrignard / tetrahydrofuran / 1 h / 16.6 - 25 °C

2.2: 20 h / 5.3 - 20 °C

3.1: toluene / 12 h / 108 - 110 °C / Sealed tube

3.2: 0.87 h / -78 - 0 °C

3.3: 20 °C

With TurboGrignard; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene;

upstream raw materials:

6-trifluoromethylnicotinic acid

6-(trifluoromethyl)nicotinoyl chloride

N-methoxy-N-methyl-6-(trifluoromethyl)pyridine-3-carboxamide

(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone

Downstream raw materials:

C₃₁H₂₃ClF₄N₆O₂

C₃₁H₂₃ClF₄N₆O₂