benzyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate

Base Information

Chemical Name:benzyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate
CAS No.:1376437-21-6
Molecular Formula:C₁₆H₁₈O₂
Molecular Weight:242.318
Hs Code.:

Synonyms:benzyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate

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Chemical Property of benzyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate

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Technology Process of benzyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate

There total 1 articles about benzyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 78277-22-2
cyclopentanecarboxylic acid benzyl ester

: 106-96-7
propargyl bromide

: 1376437-21-6
benzyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate

Guidance literature:: cyclopentanecarboxylic acid benzyl ester; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -78 - -40 ℃; for 0.25h; Inert atmosphere;

propargyl bromide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; toluene; at -78 - 25 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1376437-21-6
benzyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate

: 1376437-22-7
propan-2-yl 2-ethyl-3-[(4-iodophenyl)carbonyl]indolizine-7-carboxylate

: 1376437-23-8
propan-2-yl 3-{[4-(3-{1-[(benzyloxy)carbonyl]cyclopentyl}prop-1-yn-1-yl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate

Guidance literature:: benzyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate; propan-2-yl 2-ethyl-3-[(4-iodophenyl)carbonyl]indolizine-7-carboxylate; With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In ethyl acetate; acetonitrile; at 5 - 25 ℃; for 0.25h; Inert atmosphere;

With bis-triphenylphosphine-palladium(II) chloride; In ethyl acetate; acetonitrile; at 50 ℃; for 5h; Inert atmosphere;

Reference yield:

: 1376437-21-6
benzyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate

: 1376437-24-9
1-{3-[4-({2-ethyl-7-[(propan-2-yloxy)carbonyl]indolizine-3-yl}carbonyl)phenyl]propyl}cyclopentane carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; N-ethyl-N,N-diisopropylamine / acetonitrile; ethyl acetate / 0.25 h / 5 - 25 °C / Inert atmosphere

1.2: 5 h / 50 °C / Inert atmosphere

2.1: ammonium formate; palladium 10% on activated carbon / methanol; 1,4-dioxane / 9 h / 90 °C / Inert atmosphere

With copper(l) iodide; palladium 10% on activated carbon; ammonium formate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethyl acetate; acetonitrile;