propan-2-yl 3-{[4-(3-{1-[(benzyloxy)carbonyl]cyclopentyl}prop-1-yn-1-yl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate

Base Information

Chemical Name:propan-2-yl 3-{[4-(3-{1-[(benzyloxy)carbonyl]cyclopentyl}prop-1-yn-1-yl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate
CAS No.:1376437-23-8
Molecular Formula:C₃₇H₃₇NO₅
Molecular Weight:575.704
Hs Code.:

Synonyms:propan-2-yl 3-{[4-(3-{1-[(benzyloxy)carbonyl]cyclopentyl}prop-1-yn-1-yl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate

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Chemical Property of propan-2-yl 3-{[4-(3-{1-[(benzyloxy)carbonyl]cyclopentyl}prop-1-yn-1-yl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate

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Technology Process of propan-2-yl 3-{[4-(3-{1-[(benzyloxy)carbonyl]cyclopentyl}prop-1-yn-1-yl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate

There total 2 articles about propan-2-yl 3-{[4-(3-{1-[(benzyloxy)carbonyl]cyclopentyl}prop-1-yn-1-yl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376437-21-6
benzyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate

: 1376437-22-7
propan-2-yl 2-ethyl-3-[(4-iodophenyl)carbonyl]indolizine-7-carboxylate

: 1376437-23-8
propan-2-yl 3-{[4-(3-{1-[(benzyloxy)carbonyl]cyclopentyl}prop-1-yn-1-yl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate

Guidance literature:: benzyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate; propan-2-yl 2-ethyl-3-[(4-iodophenyl)carbonyl]indolizine-7-carboxylate; With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In ethyl acetate; acetonitrile; at 5 - 25 ℃; for 0.25h; Inert atmosphere;

With bis-triphenylphosphine-palladium(II) chloride; In ethyl acetate; acetonitrile; at 50 ℃; for 5h; Inert atmosphere;

Reference yield:

: 78277-22-2
cyclopentanecarboxylic acid benzyl ester

: 1376437-23-8
propan-2-yl 3-{[4-(3-{1-[(benzyloxy)carbonyl]cyclopentyl}prop-1-yn-1-yl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; hexane; N,N,N,N,N,N-hexamethylphosphoric triamide / 0.25 h / -78 - -40 °C / Inert atmosphere

1.2: 1 h / -78 - 25 °C / Inert atmosphere

2.1: copper(l) iodide; N-ethyl-N,N-diisopropylamine / acetonitrile; ethyl acetate / 0.25 h / 5 - 25 °C / Inert atmosphere

2.2: 5 h / 50 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; ethyl acetate; acetonitrile;