propan-2-yl 3-{[4-(3-{1-[(tert-butoxycarbonyl)amino]cyclopentyl}propyl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate

Base Information

Chemical Name:propan-2-yl 3-{[4-(3-{1-[(tert-butoxycarbonyl)amino]cyclopentyl}propyl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate
CAS No.:1376437-26-1
Molecular Formula:C₃₄H₄₄N₂O₅
Molecular Weight:560.734
Hs Code.:

Synonyms:propan-2-yl 3-{[4-(3-{1-[(tert-butoxycarbonyl)amino]cyclopentyl}propyl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate

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Chemical Property of propan-2-yl 3-{[4-(3-{1-[(tert-butoxycarbonyl)amino]cyclopentyl}propyl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate

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Technology Process of propan-2-yl 3-{[4-(3-{1-[(tert-butoxycarbonyl)amino]cyclopentyl}propyl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate

There total 4 articles about propan-2-yl 3-{[4-(3-{1-[(tert-butoxycarbonyl)amino]cyclopentyl}propyl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1376437-24-9
1-{3-[4-({2-ethyl-7-[(propan-2-yloxy)carbonyl]indolizine-3-yl}carbonyl)phenyl]propyl}cyclopentane carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1376437-26-1
propan-2-yl 3-{[4-(3-{1-[(tert-butoxycarbonyl)amino]cyclopentyl}propyl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate

Guidance literature:: 1-{3-[4-({2-ethyl-7-[(propan-2-yloxy)carbonyl]indolizine-3-yl}carbonyl)phenyl]propyl}cyclopentane carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; at 5 - 25 ℃; for 3h;

tert-butyl alcohol; With copper(l) chloride; at 115 ℃; for 18h;

Reference yield:

: 78277-22-2
cyclopentanecarboxylic acid benzyl ester

: 1376437-26-1
propan-2-yl 3-{[4-(3-{1-[(tert-butoxycarbonyl)amino]cyclopentyl}propyl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; hexane; N,N,N,N,N,N-hexamethylphosphoric triamide / 0.25 h / -78 - -40 °C / Inert atmosphere

1.2: 1 h / -78 - 25 °C / Inert atmosphere

2.1: copper(l) iodide; N-ethyl-N,N-diisopropylamine / acetonitrile; ethyl acetate / 0.25 h / 5 - 25 °C / Inert atmosphere

2.2: 5 h / 50 °C / Inert atmosphere

3.1: ammonium formate; palladium 10% on activated carbon / methanol; 1,4-dioxane / 9 h / 90 °C / Inert atmosphere

4.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 5 - 25 °C

4.2: 18 h / 115 °C

With copper(l) iodide; n-butyllithium; diphenyl phosphoryl azide; palladium 10% on activated carbon; ammonium formate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; ethyl acetate; toluene; acetonitrile;

Reference yield:

: 1376437-21-6
benzyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate

: 1376437-26-1
propan-2-yl 3-{[4-(3-{1-[(tert-butoxycarbonyl)amino]cyclopentyl}propyl)phenyl]carbonyl}-2-ethylindolizine-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; N-ethyl-N,N-diisopropylamine / acetonitrile; ethyl acetate / 0.25 h / 5 - 25 °C / Inert atmosphere

1.2: 5 h / 50 °C / Inert atmosphere

2.1: ammonium formate; palladium 10% on activated carbon / methanol; 1,4-dioxane / 9 h / 90 °C / Inert atmosphere

3.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 5 - 25 °C

3.2: 18 h / 115 °C

With copper(l) iodide; diphenyl phosphoryl azide; palladium 10% on activated carbon; ammonium formate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethyl acetate; toluene; acetonitrile;