(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate

Base Information

Chemical Name:(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate
CAS No.:1215080-63-9
Molecular Formula:C₂₅H₂₆Cl₂O₅S
Molecular Weight:509.45
Hs Code.:

Synonyms:(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of (2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate

There total 4 articles about (2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1215080-62-8
(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 3-oxobutanoate

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 1215080-63-9
(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate

Guidance literature:: With piperidine; acetic acid; In benzene; for 2h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2011.10.025

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1215080-63-9
(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

2.3: 20 °C / Inert atmosphere

3.1: pyridine / acetone / 4 h / Inert atmosphere; Reflux

4.1: piperidine; acetic acid / benzene / 2 h / Inert atmosphere; Reflux

With piperidine; pyridine; pyridinium p-toluenesulfonate; sodium hydride; acetic acid; In tetrahydrofuran; dichloromethane; acetone; mineral oil; benzene; 4.1: Knoevenagel reaction;
DOI:10.1016/j.tet.2011.10.025

Reference yield:

: 110657-96-0
2-((R)-oxiran-2-ylmethoxy)tetrahydro-2H-pyran

: 1215080-63-9
(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: pyridine / acetone / 4 h / Inert atmosphere; Reflux

3.1: piperidine; acetic acid / benzene / 2 h / Inert atmosphere; Reflux

With piperidine; pyridine; sodium hydride; acetic acid; In tetrahydrofuran; acetone; mineral oil; benzene; 3.1: Knoevenagel reaction;
DOI:10.1016/j.tet.2011.10.025