2-CHLORO-N-(3-METHYLPHENYL)PROPANAMIDE

Base Information

• Chemical Name: 2-CHLORO-N-(3-METHYLPHENYL)PROPANAMIDE
• CAS No.: 111057-88-6
• Molecular Formula: C₁₀H₁₂ClNO
• Molecular Weight: 197.664
• Mol file: 111057-88-6.mol

Synonyms:C₁₀H₁₂ClNO

Chemical Property of 2-CHLORO-N-(3-METHYLPHENYL)PROPANAMIDE

Chemical Property:

• Boiling Point: 341.9±25.0 °C(Predicted)
• PKA: 13.15±0.70(Predicted)
• Density: 1.183±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N-(3-methylphenyl)propanamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 2-CHLORO-N-(3-METHYLPHENYL)PROPANAMIDE

There total 1 articles about 2-CHLORO-N-(3-METHYLPHENYL)PROPANAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloropropionyl chloride (7623-09-8) + 1-amino-3-methylbenzene (108-44-1) → C10H12ClNO (111057-88-6)

Guidance literature:

With pyridine; In chloroform; at 20 ℃; for 12h;

DOI:10.1002/jhet.2602

Reference yield: 75.0%

2-Iodophenol (533-58-4) + C10H12ClNO (111057-88-6) → 2-methyl-4-m-tolyl-2H-1,4-benzoxazin-3(4H)-one (1134193-53-5)

Guidance literature:

With copper(l) iodide; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 130 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1021/jo802818s

Reference yield: 60.0%

C10H12ClNO (111057-88-6) + 1,3-diethyl-8-thioxo-3,7,8,9-tetrahydro-1H-purine-2,6-dione → 2-methyl-2-[(1,3-diethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)thio]-N-(3-methylphenyl)acetamide

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃; for 4h;

DOI:10.1002/jhet.2602

upstream raw materials:

2-chloropropionyl chloride

1-amino-3-methylbenzene

Downstream raw materials:

2-methyl-4-m-tolyl-2H-1,4-benzoxazin-3(4H)-one

Refernces