N-((1-bromo-8-fluoroisoquinolin-4-yl)methyl)-3-chlorobenzenamine

Base Information

Chemical Name:N-((1-bromo-8-fluoroisoquinolin-4-yl)methyl)-3-chlorobenzenamine
CAS No.:1050203-48-9
Molecular Formula:C₁₆H₁₁BrClFN₂
Molecular Weight:365.632
Hs Code.:

Synonyms:N-((1-bromo-8-fluoroisoquinolin-4-yl)methyl)-3-chlorobenzenamine

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Chemical Property of N-((1-bromo-8-fluoroisoquinolin-4-yl)methyl)-3-chlorobenzenamine

Chemical Property:

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Technology Process of N-((1-bromo-8-fluoroisoquinolin-4-yl)methyl)-3-chlorobenzenamine

There total 7 articles about N-((1-bromo-8-fluoroisoquinolin-4-yl)methyl)-3-chlorobenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1050203-47-8
1-bromo-4-(bromomethyl)-8-fluoroisoquinoline

: 108-42-9
3-chloro-aniline

: 1050203-48-9
N-((1-bromo-8-fluoroisoquinolin-4-yl)methyl)-3-chlorobenzenamine

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 2h;

Reference yield:

: 1050203-43-4
N-allyl-N-benzyl-2-fluoro-6-iodobenzamide

: 1050203-48-9
N-((1-bromo-8-fluoroisoquinolin-4-yl)methyl)-3-chlorobenzenamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-cyclohexyl-cyclohexanamine / palladium diacetate; triphenylphosphine / ISOPROPYLAMIDE / 18 h / 100 °C

2.1: sulfuric acid; water / 2.5 h / 150 °C

3.1: phosphorus tribromide; phosphorus(V) oxybromide / 4 h / 120 °C

3.2: pH 9

4.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 80 °C

5.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 40 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; water; phosphorus tribromide; sodium carbonate; N-cyclohexyl-cyclohexanamine; phosphorus(V) oxybromide; palladium diacetate; triphenylphosphine; In tetrachloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;

Reference yield:

: 372-19-0
meta-fluoroaniline

: 1050203-48-9
N-((1-bromo-8-fluoroisoquinolin-4-yl)methyl)-3-chlorobenzenamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid; sodium nitrite / water / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / diethyl ether / 1 h / -70 °C

2.2: 1 h / -50 °C

2.3: pH 1

3.1: thionyl chloride / 0.25 h / 80 °C

3.2: 2 h / 5 - 20 °C

4.1: N-cyclohexyl-cyclohexanamine / palladium diacetate; triphenylphosphine / ISOPROPYLAMIDE / 18 h / 100 °C

5.1: sulfuric acid; water / 2.5 h / 150 °C

6.1: phosphorus tribromide; phosphorus(V) oxybromide / 4 h / 120 °C

6.2: pH 9

7.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 80 °C

8.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 40 °C

With N-Bromosuccinimide; n-butyllithium; thionyl chloride; 2,2'-azobis(isobutyronitrile); sulfuric acid; water; phosphorus tribromide; sodium carbonate; N-ethyl-N,N-diisopropylamine; N-cyclohexyl-cyclohexanamine; sodium nitrite; phosphorus(V) oxybromide; palladium diacetate; triphenylphosphine; In tetrachloromethane; diethyl ether; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;