Technology Process of 3,6,6-trimethyl-3-(3-oxopropyl)-cyclohex-1-enecarboxylic acid methyl ester
There total 8 articles about 3,6,6-trimethyl-3-(3-oxopropyl)-cyclohex-1-enecarboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-(3-hydroxypropyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -78 ℃;
Inert atmosphere;
With
triethylamine;
In
dichloromethane;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1002/chem.200800930
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C / Inert atmosphere
1.2: -78 °C / Inert atmosphere
2.1: copper(l) iodide / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere
2.2: 1 h / -20 °C / Inert atmosphere
2.3: -20 - 20 °C / Inert atmosphere
3.1: palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 20 °C
4.1: pyridine; hydrogen fluoride; water / acetonitrile / 0 - 20 °C / Inert atmosphere
5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere
5.2: 2 h / -78 - 20 °C / Inert atmosphere
With
pyridine; copper(l) iodide; oxalyl dichloride; hydrogen fluoride; water; palladium diacetate; dimethyl sulfoxide; triethylamine; triphenylphosphine; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
5.1: Swern oxidation / 5.2: Swern oxidation;
DOI:10.1039/c0ob01086c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper(l) iodide / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere
1.2: 1 h / -20 °C / Inert atmosphere
1.3: -20 - 20 °C / Inert atmosphere
2.1: palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 20 °C
3.1: pyridine; hydrogen fluoride; water / acetonitrile / 0 - 20 °C / Inert atmosphere
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere
4.2: 2 h / -78 - 20 °C / Inert atmosphere
With
pyridine; copper(l) iodide; oxalyl dichloride; hydrogen fluoride; water; palladium diacetate; dimethyl sulfoxide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
4.1: Swern oxidation / 4.2: Swern oxidation;
DOI:10.1039/c0ob01086c
