trifluoromethanesulfonic acid 3-(3-(tert-butyldimethylsilanyloxy)propyl)-3,6,6-trimethylcyclohex-1-enyl ester

Base Information

Chemical Name:trifluoromethanesulfonic acid 3-(3-(tert-butyldimethylsilanyloxy)propyl)-3,6,6-trimethylcyclohex-1-enyl ester
CAS No.:1071178-92-1
Molecular Formula:C₁₉H₃₅F₃O₄SSi
Molecular Weight:444.631
Hs Code.:

Synonyms:trifluoromethanesulfonic acid 3-(3-(tert-butyldimethylsilanyloxy)propyl)-3,6,6-trimethylcyclohex-1-enyl ester

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Chemical Property of trifluoromethanesulfonic acid 3-(3-(tert-butyldimethylsilanyloxy)propyl)-3,6,6-trimethylcyclohex-1-enyl ester

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Technology Process of trifluoromethanesulfonic acid 3-(3-(tert-butyldimethylsilanyloxy)propyl)-3,6,6-trimethylcyclohex-1-enyl ester

There total 7 articles about trifluoromethanesulfonic acid 3-(3-(tert-butyldimethylsilanyloxy)propyl)-3,6,6-trimethylcyclohex-1-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1071178-87-4
3-(3-(tert-butyldimethylsilanyloxy)propyl)-6,6-dimethylcyclohex-2-enone

: 75-16-1
methylmagnesium bromide

: 145100-51-2
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide

: 1071178-92-1
trifluoromethanesulfonic acid 3-(3-(tert-butyldimethylsilanyloxy)propyl)-3,6,6-trimethylcyclohex-1-enyl ester

Guidance literature:: methylmagnesium bromide; With copper(l) iodide; In tetrahydrofuran; at -20 ℃; for 1h; Inert atmosphere;

3-(3-(tert-butyldimethylsilanyloxy)propyl)-6,6-dimethylcyclohex-2-enone; In tetrahydrofuran; at -20 ℃; for 1h; Inert atmosphere;

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide; In tetrahydrofuran; at -20 - 20 ℃; Inert atmosphere;
DOI:10.1039/c0ob01086c

Reference yield: 79.0%

: 1071178-87-4
3-(3-(tert-butyldimethylsilanyloxy)propyl)-6,6-dimethylcyclohex-2-enone

: 917-54-4
methyllithium

: 145100-51-2
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide

: 1071178-92-1
trifluoromethanesulfonic acid 3-(3-(tert-butyldimethylsilanyloxy)propyl)-3,6,6-trimethylcyclohex-1-enyl ester

Guidance literature:: methyllithium; With copper(l) iodide; In tetrahydrofuran; at -20 - 0 ℃; Inert atmosphere;

3-(3-(tert-butyldimethylsilanyloxy)propyl)-6,6-dimethylcyclohex-2-enone; In tetrahydrofuran; at -20 - 20 ℃; Inert atmosphere;

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide; In tetrahydrofuran; at 0 - 20 ℃; for 5h; Inert atmosphere;
DOI:10.1002/chem.200800930

Reference yield:

: 1071179-31-1
3-(3-(tert-butyldimethylsilyloxy)propyl)-6-methylcyclohex-2-enone

: 1071178-92-1
trifluoromethanesulfonic acid 3-(3-(tert-butyldimethylsilanyloxy)propyl)-3,6,6-trimethylcyclohex-1-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: copper(l) iodide / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

2.2: 1 h / -20 °C / Inert atmosphere

2.3: -20 - 20 °C / Inert atmosphere

With copper(l) iodide; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1039/c0ob01086c