3-(3-hydroxypropyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

Base Information

Chemical Name:3-(3-hydroxypropyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester
CAS No.:1071179-38-8
Molecular Formula:C₁₄H₂₄O₃
Molecular Weight:240.343
Hs Code.:

Synonyms:3-(3-hydroxypropyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

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Chemical Property of 3-(3-hydroxypropyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

Chemical Property:

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Technology Process of 3-(3-hydroxypropyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

There total 7 articles about 3-(3-hydroxypropyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1071179-35-5
3-(3-(tert-butyldimethylsilanyloxy)-propyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

: 1071179-38-8
3-(3-hydroxypropyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: With pyridine; hydrogen fluoride; water; In acetonitrile; at 0 - 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1002/chem.200800930

Reference yield:

: 1071179-31-1
3-(3-(tert-butyldimethylsilyloxy)propyl)-6-methylcyclohex-2-enone

: 1071179-38-8
3-(3-hydroxypropyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: copper(l) iodide / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

2.2: 1 h / -20 °C / Inert atmosphere

2.3: -20 - 20 °C / Inert atmosphere

3.1: palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 20 °C

4.1: pyridine; hydrogen fluoride; water / acetonitrile / 0 - 20 °C / Inert atmosphere

With pyridine; copper(l) iodide; hydrogen fluoride; water; palladium diacetate; triethylamine; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c0ob01086c

Reference yield:

: 1071178-87-4
3-(3-(tert-butyldimethylsilanyloxy)propyl)-6,6-dimethylcyclohex-2-enone

: 1071179-38-8
3-(3-hydroxypropyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

1.2: 1 h / -20 °C / Inert atmosphere

1.3: -20 - 20 °C / Inert atmosphere

2.1: palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 20 °C

3.1: pyridine; hydrogen fluoride; water / acetonitrile / 0 - 20 °C / Inert atmosphere

With pyridine; copper(l) iodide; hydrogen fluoride; water; palladium diacetate; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c0ob01086c