2,5-Bis(4-chlorophenyl)pyrazine

Base Information

Chemical Name:2,5-Bis(4-chlorophenyl)pyrazine
CAS No.:74376-33-3
Molecular Formula:C₁₆H₁₀Cl₂N₂
Molecular Weight:301.175
Hs Code.:
DSSTox Substance ID:DTXSID201304388
Nikkaji Number:J1.447.557E

Synonyms:2,5-Bis(4-chlorophenyl)pyrazine;DTXSID201304388;2,5-Bis(4-chlorophenyl)pyrazine #;STL145219;AKOS005746292;Pyrazine, 2,5-bis(4-chlorophenyl)-;74376-33-3

Suppliers and Price of 2,5-Bis(4-chlorophenyl)pyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,5-Bis(4-chlorophenyl)pyrazine

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:300.0221037
Heavy Atom Count:20
Complexity:267

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CN=C(C=N2)C3=CC=C(C=C3)Cl)Cl

Technology Process of 2,5-Bis(4-chlorophenyl)pyrazine

There total 7 articles about 2,5-Bis(4-chlorophenyl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 23229-26-7
2-5-dibromopyrazine

: 1679-18-1
4-Chlorophenylboronic acid

: 74376-33-3
2,5-bis(4-chlorophenyl)pyrazine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 80 ℃; for 24h; Inert atmosphere;

Reference yield: 85.0%

: 1458055-80-5
C₁₀H₈BrClO₂

: 74376-33-3
2,5-bis(4-chlorophenyl)pyrazine

Guidance literature:: With ammonium formate; In N,N-dimethyl-formamide; at 120 ℃; for 6h; regioselective reaction; Schlenk technique;
DOI:10.1039/c3ob41164h

Reference yield: 55.0%

: 26086-60-2
2-azido-4'-chloroacetophenone

: 74376-33-3
2,5-bis(4-chlorophenyl)pyrazine

Guidance literature:: With 1% Pd on activated carbon; hydrogen; In glycerol; at 25 ℃; for 24h; under 2280.15 Torr; Autoclave;
DOI:10.1002/ejoc.201900722