133345-21-8

Basic information

• Product Name: 1-(4-Acetoxyphenyl)-4-acetylpiperazine
• Synonyms: 1-(4-Acetoxyphenyl)-4-acetylpiperazine
• CAS NO: 133345-21-8
• Molecular Weight: 262.309
• Mol File: 133345-21-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 455.6±40.0 °C(Predicted)
• Density: 1.183±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-(4-Acetoxyphenyl)-4-acetylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Acetoxyphenyl)-4-acetylpiperazine(133345-21-8)
• EPA Substance Registry System: 1-(4-Acetoxyphenyl)-4-acetylpiperazine(133345-21-8)

Safety Data

• Hazardous Substances Data: 133345-21-8(Hazardous Substances Data)

Usage

General Description

1-(4-Acetoxyphenyl)-4-acetylpiperazine is a chemical compound that belongs to the class of piperazines. It has two acetyl groups attached to the piperazine ring, and a 4-acetoxyphenyl group attached at one of the nitrogen atoms of the piperazine ring. 1-(4-Acetoxyphenyl)-4-acetylpiperazine is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It has potential therapeutic applications due to its ability to modulate serotonin and dopamine receptors in the central nervous system, making it a potential candidate for the development of drugs targeting neurological disorders such as depression, anxiety, and schizophrenia. Additionally, it is also used as a research chemical in the study of receptor binding and drug design.

Upstream product

• 38869-37-3 1-(4-hydroxy-phenyl)-piperazine dihydrobromide 
• 108-24-7 acetic anhydride 
• 56621-48-8 1-(4-hydroxyphenyl)piperazine 
• 38212-30-5 4-(4-methoxyphenyl)piperazine 
• 38869-47-5 4-(p-methoxyphenyl)piperazine dihydrochloride 
• 75-36-5 acetyl chloride 

Downstream Products

• 65277-42-1 trans-Ketoconazole 
• 145782-08-7 cis-1-acetyl-4-<-<<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>piperazine 
• 145782-08-7 trans-1-acetyl-4-<-<<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>piperazine 
• 65277-42-1 ketoconazole 
• 67914-60-7 N-acetyl-N'-(4-hydroxyphenyl)piperazine 

Relevant articles and documents

Partial structures of ketoconazole as modulators of the large conductance calcium-activated potassium channel (BKCa)

A series of partial structures of ketoconazole has been synthesized and tested for activity on the large conductance calcium-activated potassium channel (BK) in bovine smooth muscle cells. This has provided openers and blockers of the channel. The results suggest that the phenyl and phenoxy moieties are important for interaction with BK, whereas the imidazole group is unimportant. The properties of the phenoxy moiety seem to determine whether the compounds act to open or block the channel.

Synthesis and antifungal activity of structural analogues of bifonazole and ketoconazole

The synthesis and antifungal activities of the cis- and trans-1-acetyl-4-[4-[[2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-l-ylmethyl )-1,3-dioxolan-4-yl]-methoxy]phenyl]piperazines 3 and 4 are reported. Stereochemical assignments to diastereomeric pairs of cis/trans isomers were made on the basis of 1H and 13C-NMR data. Among test derivatives the best activity was shown by the benzoyl esters of the cis- and trans-[2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan- 4-yl]methanols 9 and 10.