6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)thioamide

Base Information

Chemical Name:6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)thioamide
CAS No.:1464139-77-2
Molecular Formula:C₂₇H₂₈N₄O₂S
Molecular Weight:472.611
Hs Code.:

Synonyms:6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)thioamide

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Chemical Property of 6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)thioamide

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Technology Process of 6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)thioamide

There total 7 articles about 6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)thioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1464139-76-1
6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)amide

: 1464139-77-2
6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)thioamide

Guidance literature:: With Lawessons reagent; In toluene; for 1h; Reflux;

Reference yield:

: 392-04-1
methyl 4-fluoro-2-hydroxybenzoate

: 1464139-77-2
6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)thioamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: aluminum (III) chloride / dichloromethane / 0.08 h

1.2: Reflux

2.1: sodium carbonate / N,N-dimethyl-formamide / 60 °C

3.1: hydrazine / tetrahydrofuran

4.1: water; sodium hydroxide / tetrahydrofuran / Reflux

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide

6.1: Lawessons reagent / toluene / 1 h / Reflux

With Lawessons reagent; dmap; aluminum (III) chloride; water; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; hydrazine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1464139-72-7
4-fluoro-2-hydroxy-5-propionyl-benzoic acid methyl ester

: 1464139-77-2
6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)thioamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / N,N-dimethyl-formamide / 60 °C

2: hydrazine / tetrahydrofuran

3: water; sodium hydroxide / tetrahydrofuran / Reflux

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide

5: Lawessons reagent / toluene / 1 h / Reflux

With Lawessons reagent; dmap; water; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; hydrazine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;