1-ethoxy-3-phenylisoquinoline

Base Information

• Chemical Name: 1-ethoxy-3-phenylisoquinoline
• CAS No.: 245122-81-0
• Molecular Formula: C₁₇H₁₅NO
• Molecular Weight: 249.312
• Mol file: 245122-81-0.mol

Synonyms:1-ethoxy-3-phenylisoquinoline

Chemical Property of 1-ethoxy-3-phenylisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-ethoxy-3-phenylisoquinoline

There total 13 articles about 1-ethoxy-3-phenylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-(dimethyl(oxo)-λ6-sulfaneylidene)-1-phenylethan-1-one (20718-17-6) + benzimidic acid ethyl ester (825-60-5) → 1-ethoxy-3-phenylisoquinoline (245122-81-0)

Guidance literature:

With 3,5-dimethylbenzoic acid; [RhCl₂(p-cymene)]2; In ethanol; 2,2,2-trifluoroethanol; at 20 - 100 ℃; for 12h; Reagent/catalyst; Solvent; Temperature; Time; Catalytic behavior; Inert atmosphere;

DOI:10.1002/adsc.201800844

Reference yield: 52.0%

ethanol (64-17-5) + 2-(phenylethynyl)benzonitrile (32183-76-9) → 3-phenyl-2H-isoquinolin-1-one (7115-13-1) + 1-ethoxy-3-phenylisoquinoline (245122-81-0) + ethyl 2-(phenylethynyl)benzoate (110166-71-7)

Guidance literature:

With hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); at 78 ℃; for 16h; regioselective reaction;

DOI:10.1016/j.tetlet.2010.09.136

Reference yield: 48.0%

ethanol (64-17-5) + 2-(phenylethynyl)benzonitrile (32183-76-9) → 3-phenyl-2H-isoquinolin-1-one (7115-13-1) + 1-ethoxy-3-phenylisoquinoline (245122-81-0)

Guidance literature:

With hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); for 16h; regioselective reaction; Reflux;

DOI:10.1016/j.tetlet.2010.09.136

upstream raw materials:

1-chloro-3-phenylisoquinoline

sodium ethanolate

phenylacetylene

ethyl 2-(phenylethynyl)benzoate

Downstream raw materials:

3-phenylisoquinoline-1-ol

3-phenyl-2H-isoquinolin-1-one