N-α-benzyloxycarbonylglycine-N-(2-t-butyldimethylsilyloxy-1-ethyl)amide

Base Information

Chemical Name:N-α-benzyloxycarbonylglycine-N-(2-t-butyldimethylsilyloxy-1-ethyl)amide
CAS No.:252234-22-3
Molecular Formula:C₁₈H₃₀N₂O₄Si
Molecular Weight:366.533
Hs Code.:

Synonyms:N-α-benzyloxycarbonylglycine-N-(2-t-butyldimethylsilyloxy-1-ethyl)amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-α-benzyloxycarbonylglycine-N-(2-t-butyldimethylsilyloxy-1-ethyl)amide

Chemical Property:

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Technology Process of N-α-benzyloxycarbonylglycine-N-(2-t-butyldimethylsilyloxy-1-ethyl)amide

There total 2 articles about N-α-benzyloxycarbonylglycine-N-(2-t-butyldimethylsilyloxy-1-ethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4815-67-2
N-benzyloxycarbonylglycylaminoethanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 252234-22-3
N-α-benzyloxycarbonylglycine-N-(2-t-butyldimethylsilyloxy-1-ethyl)amide

Guidance literature:: With 1H-imidazole; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1021/ja993674m

Reference yield:

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 252234-22-3
N-α-benzyloxycarbonylglycine-N-(2-t-butyldimethylsilyloxy-1-ethyl)amide

Guidance literature:: Multi-step reaction with 2 steps

1: EDC; HOBt / dimethylformamide / 20 °C

2: 7.19 g / imidazole / dimethylformamide; CH₂Cl₂ / 0 °C

With 1H-imidazole; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Addition;
DOI:10.1021/ja993674m

Reference yield:

: 252234-22-3
N-α-benzyloxycarbonylglycine-N-(2-t-butyldimethylsilyloxy-1-ethyl)amide

: 252234-24-5
6-(2-hydroxy-5-methoxy-phenyl)-hex-5-enoic acid {[2-(tert-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-methyl}-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / H₂ / Pd/C / ethanol / 18 h

2.1: EDC; HOBt; diisopropylethylamine / dimethylformamide / 0.5 h / 0 °C

2.2: 92 percent / dimethylformamide / 0 - 20 °C

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; 1.1: Elimination / 2.1: Addition / 2.2: Addition;
DOI:10.1021/ja993674m