tert-butyl 2-[((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-(tert-butoxycarbonyl)amino)]ethyl(methyl)carbamate

Base Information

Chemical Name:tert-butyl 2-[((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-(tert-butoxycarbonyl)amino)]ethyl(methyl)carbamate
CAS No.:1051930-06-3
Molecular Formula:C₂₆H₄₃BN₂O₆
Molecular Weight:490.448
Hs Code.:

Synonyms:tert-butyl 2-[((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-(tert-butoxycarbonyl)amino)]ethyl(methyl)carbamate

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Chemical Property of tert-butyl 2-[((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-(tert-butoxycarbonyl)amino)]ethyl(methyl)carbamate

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Technology Process of tert-butyl 2-[((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-(tert-butoxycarbonyl)amino)]ethyl(methyl)carbamate

There total 5 articles about tert-butyl 2-[((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-(tert-butoxycarbonyl)amino)]ethyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 875339-45-0
tert-butyl (2-((3-bromobenzyl)(tert-butoxycarbonyl)amino)-ethyl)(methyl)-carbamate

: 73183-34-3
bis(pinacol)diborane

: 1051930-06-3
tert-butyl 2-[((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-(tert-butoxycarbonyl)amino)]ethyl(methyl)carbamate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 4h; Inert atmosphere;

Reference yield: 82.0%

: tert-butyl 2-[(3-iodobenzyl)-(tert-butoxycarbonyl)amino]ethyl(methyl)carbamate

: 73183-34-3
bis(pinacol)diborane

: 1051930-06-3
tert-butyl 2-[((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-(tert-butoxycarbonyl)amino)]ethyl(methyl)carbamate

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; at 80 ℃; for 16h;

Reference yield:

: 121492-06-6
(2-aminoethyl)methylcarbamic acid tert-butyl ester

: 1051930-06-3
tert-butyl 2-[((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-(tert-butoxycarbonyl)amino)]ethyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / methanol / 0.25 h / Cooling

1.2: 1 h / Cooling

2.1: sodium hydrogencarbonate; di-tert-butyl dicarbonate / tetrahydrofuran / 20 °C

3.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 4 h / 80 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; di-tert-butyl dicarbonate; potassium acetate; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; methanol; dimethyl sulfoxide;