(3R,4R,1'R)-4-benzyloxymethyl-3-ethyl-1-(1'-phenylethyl)pyrrolidin-2-one

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Chemical Name:(3R,4R,1'R)-4-benzyloxymethyl-3-ethyl-1-(1'-phenylethyl)pyrrolidin-2-one
CAS No.:637014-21-2
Molecular Formula:C₂₂H₂₇NO₂
Molecular Weight:337.462
Hs Code.:

Synonyms:(3R,4R,1'R)-4-benzyloxymethyl-3-ethyl-1-(1'-phenylethyl)pyrrolidin-2-one

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Chemical Property of (3R,4R,1'R)-4-benzyloxymethyl-3-ethyl-1-(1'-phenylethyl)pyrrolidin-2-one

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Technology Process of (3R,4R,1'R)-4-benzyloxymethyl-3-ethyl-1-(1'-phenylethyl)pyrrolidin-2-one

There total 3 articles about (3R,4R,1'R)-4-benzyloxymethyl-3-ethyl-1-(1'-phenylethyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 75-03-6
ethyl iodide

: 637014-18-7
(4R,1'R)-4-benzyloxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one

: 637014-21-2
(3R,4R,1'R)-4-benzyloxymethyl-3-ethyl-1-(1'-phenylethyl)pyrrolidin-2-one

Guidance literature:: (4R,1'R)-4-benzyloxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -15 ℃; for 0.333333h;

ethyl iodide; In tetrahydrofuran; hexane; at -15 ℃; for 2h;
DOI:10.3987/com-03-9854

Reference yield:

: 100-39-0
benzyl bromide

: 637014-21-2
(3R,4R,1'R)-4-benzyloxymethyl-3-ethyl-1-(1'-phenylethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: HMPA; Ph₃CH; n-BuLi / tetrahydrofuran; hexane / 0.33 h / -15 °C

1.2: 91 percent / tetrahydrofuran; hexane / 1 h / Heating

2.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -15 °C

2.2: 76 percent / tetrahydrofuran; hexane / 2 h / -15 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; triphenylmethane; In tetrahydrofuran; hexane;
DOI:10.3987/com-03-9854

Reference yield:

: 190957-22-3
(4R,1'R)-1-(1'-phenylethyl)-4-hydroxymethylpyrrolidin-2-one

: 637014-21-2
(3R,4R,1'R)-4-benzyloxymethyl-3-ethyl-1-(1'-phenylethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: HMPA; Ph₃CH; n-BuLi / tetrahydrofuran; hexane / 0.33 h / -15 °C

1.2: 91 percent / tetrahydrofuran; hexane / 1 h / Heating

2.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -15 °C

2.2: 76 percent / tetrahydrofuran; hexane / 2 h / -15 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; triphenylmethane; In tetrahydrofuran; hexane;
DOI:10.3987/com-03-9854