ethyl (4-benzothiazol-2-ylbenzyl)phosphonochloridate hydrochloride

Base Information

• Chemical Name: ethyl (4-benzothiazol-2-ylbenzyl)phosphonochloridate hydrochloride
• CAS No.: 104608-47-1
• Molecular Formula: C₁₆H₁₅ClNO₂PS*ClH
• Molecular Weight: 388.254
• Mol file: 104608-47-1.mol

Synonyms:ethyl (4-benzothiazol-2-ylbenzyl)phosphonochloridate hydrochloride

Chemical Property of ethyl (4-benzothiazol-2-ylbenzyl)phosphonochloridate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (4-benzothiazol-2-ylbenzyl)phosphonochloridate hydrochloride

There total 3 articles about ethyl (4-benzothiazol-2-ylbenzyl)phosphonochloridate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

fostedil (75889-62-2) → ethyl (4-benzothiazol-2-ylbenzyl)phosphonochloridate hydrochloride (104608-47-1)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; for 3h; Heating;

DOI:10.1021/jm00170a024

Reference yield:

2-<4-(bromomethyl)phenyl>benzothiazole (24239-18-7) → ethyl (4-benzothiazol-2-ylbenzyl)phosphonochloridate hydrochloride (104608-47-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.6 g / 0.25 h / 130 - 140 °C

2: 1) NaOH, 2) 1N HCl / 1) EtOH, reflux, 3 h; 2) pH 1.5

3: SOCl₂

With hydrogenchloride; sodium hydroxide; thionyl chloride;

DOI:10.1248/cpb.38.676

Reference yield:

Ethyl Hydrogen 4-(Benzothiazol-2-yl)benzylphosphonate (104608-45-9) → ethyl (4-benzothiazol-2-ylbenzyl)phosphonochloridate hydrochloride (104608-47-1)

Guidance literature:

With thionyl chloride;

DOI:10.1248/cpb.38.676

upstream raw materials:

Ethyl Hydrogen 4-(Benzothiazol-2-yl)benzylphosphonate

fostedil

2-<4-(bromomethyl)phenyl>benzothiazole

Downstream raw materials:

(4-Benzothiazol-2-yl-benzyl)-pyrrolidin-1-yl-phosphinic acid ethyl ester

(4-Benzothiazol-2-yl-benzyl)-piperidin-1-yl-phosphinic acid ethyl ester

(4-Benzothiazol-2-yl-benzyl)-morpholin-4-yl-phosphinic acid ethyl ester

(4-Benzothiazol-2-yl-benzyl)-(4-methyl-piperazin-1-yl)-phosphinic acid ethyl ester