104608-45-9

Upstream product

• 75889-62-2 fostedil 
• 24239-18-7 2-<4-(bromomethyl)phenyl>benzothiazole 

Downstream Products

• 75926-00-0 Ethyl Methyl 4-(Benzothiazol-2-yl)benzylphosphonate 
• 75925-94-9 (4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester propyl ester 
• 128766-82-5 (4-Benzothiazol-2-yl-benzyl)-phosphonic acid sec-butyl ester ethyl ester 
• 128766-81-4 Isobutyl Ethyl 4-(Benzothiazol-2-yl)benzylphosphonate 
• 128766-84-7 (4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2-fluoro-ethyl ester 
• 128766-86-9 (4-Benzothiazol-2-yl-benzyl)-phosphonic acid 2-bromo-ethyl ester ethyl ester 
• 128766-83-6 (4-Benzothiazol-2-yl-benzyl)-phosphonic acid 2,2-dimethyl-propyl ester ethyl ester 
• 128766-90-5 Ethyl 3-Hydroxypropyl 4-(Benzothiazol-2-yl)benzylphosphonate 
• 128766-87-0 (4-Benzothiazol-2-yl-benzyl)-phosphonic acid 3-bromo-propyl ester ethyl ester 
• 128766-88-1 (4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2,2,2-trifluoro-ethyl ester 
• 128766-95-0 Ethyl 3-Acetoxypropyl 4-(Benzothiazol-2-yl)benzylphosphonate 
• 128766-93-8 Ethyl 3-Nitroxypropyl 4-(Benzothiazol-2-yl)benzylphosphonate 
• 104608-47-1 ethyl (4-benzothiazol-2-ylbenzyl)phosphonochloridate hydrochloride 

Relevant academic research and scientific papers

Organic phosphorus compounds. IV. Asymmetric 4-(benzothiazol-2-yl)benzylphosphonates as potent calcium antagonistic vasodilators.

Various asymmetric or cyclic ester derivatives of the phosphonic acid moiety in the calcium antagonist fostedil (KB-944) were synthesized. The coronary vasodilator activity of these compounds was assessed by Langendorff's method. Among them, the ethyl isopropyl ester 12 showed the most potent activity, which was comparable to that of fostedil.