75889-62-2

Usage

Uses

Vasodilator (calcium channel blocker).

InChI:InChI=1/C18H20NO3PS/c1-3-21-23(20,22-4-2)13-14-9-11-15(12-10-14)18-19-16-7-5-6-8-17(16)24-18/h5-12H,3-4,13H2,1-2H3

Upstream product

• 24239-18-7 2-<4-(bromomethyl)phenyl>benzothiazole 
• 17448-38-3 Diethyl Isopropyl Phosphite 
• 122-52-1 triethyl phosphite 
• 56108-06-6 p-toluimidic acid methyl ester 
• 78-40-0 triethyl phosphate 
• 104-87-0 4-methyl-benzaldehyde 
• 137-07-5 2-amino-benzenethiol 
• 16112-21-3 2-(4-methylphenyl)-1,3-benzothiazole 

Downstream Products

• 1228700-03-5 [4-[2-[7-[2-(4-benzothiazol-2-ylphenyl)vinyl]-9,9-didecyl-9H-fluoren-2-yl]vinyl]phenyl]dibutylamine 
• 1326307-81-6 (E)-4-(4-(benzo[d]thiazol-2-yl)styryl)-N,N-bis(4-bromophenyl)aniline 
• 1326307-82-7 (E)-2-(4-(2-(2,5-dibromothiophen-3-yl)vinyl)phenyl)benzo[d]thiazole 
• 101078-64-2 diethyl 4-(6-aminobenzothiazol-2-yl)benzylphosphonate hydrochloride 
• 101078-65-3 diethyl 4-<6-(acetylamino)benzothiazol-2-yl>benzylphosphonate 
• 101078-63-1 diethyl 4-(6-nitrobenzothiazol-2-yl)benzylphosphonate 
• 101078-72-2 4-benzothiazol-2-ylbenzylphosphonic acid 
• 104608-47-1 ethyl (4-benzothiazol-2-ylbenzyl)phosphonochloridate hydrochloride 
• 104608-45-9 Ethyl Hydrogen 4-(Benzothiazol-2-yl)benzylphosphonate 
• 128766-93-8 Ethyl 3-Nitroxypropyl 4-(Benzothiazol-2-yl)benzylphosphonate 
• 128766-92-7 (4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2-nitrooxy-ethyl ester 
• 128766-95-0 Ethyl 3-Acetoxypropyl 4-(Benzothiazol-2-yl)benzylphosphonate 
• 128766-91-6 (4-Benzothiazol-2-yl-benzyl)-phosphonic acid 2-ethoxy-ethyl ester ethyl ester 
• 128766-88-1 (4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2,2,2-trifluoro-ethyl ester 

Relevant academic research and scientific papers

Benzothiazole derivatives containing different electron acceptors exhibiting totally different data-storage performances

Two small conjugated molecules BTVCz-NO2 and BTVCz, each incorporating an electron-donating carbazole group and a medium electron-withdrawing benzothiazole group, were both successfully designed and synthesized. Molecule BTVCz-NO2 is

Glycosylated star-shaped conjugated oligomers for targeted two-photon fluorescence imaging

A glucopyranose functionalized star-shaped oligomer, N-tris{4,4',4"- [(1E)-2-(2-{(E)-2-[4-(benzo[d]thiazol-2-yl)phenyl]vinyl}-9,9-bis(6-2-amido-2- deoxy-1-thio-β-D-glucopyranose-hexyl)-9H-fluoren-7-yl)vinyl]phenyl} phenylamine (TVFVBN-S-NH2), i

Synthesis and photovoltaic properties of two-dimensional D-A copolymers with conjugated side chains

Four novel two-dimensional (2D) donor-acceptor (D-A) type copolymers with different conjugated side chains, P1, P2, P3, and P4 (see Fig. 1), are designed and synthesized for the application as donor materials in polymer solar cells (PSCs). To the best of

The synthesis and optical properties of benzothiazole-based derivatives with various π-electron donors as novel bipolar fluorescent compounds

Novel bipolar benzothiazole-based derivatives with various π-electron donors were synthesized and characterized using 1H and 13C NMR and mass spectrometry; their thermal, optical and electrochemical properties were also investigated. Optoelectronic properties are reported and discussed in terms of the distribution of the highest occupied molecular orbital and the lowest unoccupied molecular orbital and the conjugative pathway between the electron-donating moieties and electron-accepting moieties. The compounds exhibited high fluorescence quantum yield, desirable HOMO levels and high thermal stability. Quantum chemical calculations were used to study optimized ground-state geometry as well as spatial distributions of HOMO and LUMO levels of the compounds.

Synthesis of fostedil (diethyl 4-(2-benzothiazolyl)benzylphosphonate) from N-acylimidates

Fostedil (diethyl 4-(benzothiazol-2-yl) benzylphosphonate) 7 has been synthesized efficiently by treatment of 2-(4-bromomethylphenyl) benzothiazole 6 with triethylphosphite. The latter (6) has been prepared by bromation of benzothiazole 3c. N-acylimidates 1(a-d) react with 2-aminobenzenethiol 2 to lead to the corresponding benzothiazoles 3(a-d) after elimination of primary amide 5. The structure of these products have been unequivocally confirmed by means of IR, 1H, 13C, and 31P NMR spectroscopy and mass spectra.

Organic phosphorus compounds. IV. Asymmetric 4-(benzothiazol-2-yl)benzylphosphonates as potent calcium antagonistic vasodilators.

Various asymmetric or cyclic ester derivatives of the phosphonic acid moiety in the calcium antagonist fostedil (KB-944) were synthesized. The coronary vasodilator activity of these compounds was assessed by Langendorff's method. Among them, the ethyl isopropyl ester 12 showed the most potent activity, which was comparable to that of fostedil.

Organic Phosphorus Compounds. 1. 4-(Benzothiazol-2-yl)benzylphosphonate as Potent Calcium Antagonistic Vasodilator

A series of 4-(benzothiazol-2-yl)benzylphosphonic acid dialkyl ester were synthesized and evaluated for coronary vasodilatory activity by Langendorff's method in the isolated guinea pig heart. Many of the phosphonic acid dialkyl esters exhibited vasodilat