1-(4-Bromophenyl)-1-methylethylamine

Base Information

• Chemical Name: 1-(4-Bromophenyl)-1-methylethylamine
• CAS No.: 17797-12-5
• Molecular Formula: C9H12BrN
• Molecular Weight: 214.105
• Hs Code.: 2921499090
• Mol file: 17797-12-5.mol

Synonyms:Benzylamine,p-bromo-a,a-dimethyl- (8CI);

Chemical Property of 1-(4-Bromophenyl)-1-methylethylamine

Chemical Property:

• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.556
• Boiling Point: 267.744 °C at 760 mmHg
• PKA: 9.15±0.10(Predicted)
• Flash Point: 115.728 °C
• PSA: 26.02000
• Density: 1.343 g/cm³
• LogP: 3.34320
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

2-(4-Bromophenyl)propan-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(4-Bromophenyl)propan-2-amine acts as a reagent for the synthesis of biaryl diamides as potent melanin concentrating hormone receptor 1 antagonist.

Technology Process of 1-(4-Bromophenyl)-1-methylethylamine

There total 8 articles about 1-(4-Bromophenyl)-1-methylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-bromobenzenecarbonitrile (623-00-7) + methyllithium (917-54-4) → 1-(4-bromophenyl)-1-methylethylamine (17797-12-5)

Guidance literature:

With cerium(III) chloride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2007.01.086

Reference yield: 90.0%

4-bromobenzenecarbonitrile (623-00-7) + methylmagnesium bromide (75-16-1) → 1-(4-bromophenyl)-1-methylethylamine (17797-12-5)

Guidance literature:

4-bromobenzenecarbonitrile; methylmagnesium bromide; In diethyl ether; for 0.5h;

With titanium(IV) isopropylate; In diethyl ether; for 6h; Reflux;

With water; sodium hydroxide; In diethyl ether; at 0 - 20 ℃; for 0.5h;

Reference yield: 72.0%

4-Bromophenylacetonitrile (16532-79-9) + methylmagnesium bromide (75-16-1) → 1-(4-bromophenyl)-1-methylethylamine (17797-12-5)

Guidance literature:

4-Bromophenylacetonitrile; methylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

With titanium(IV) isopropylate; In tetrahydrofuran; at 50 ℃; for 12h;

With water; sodium hydroxide; In tetrahydrofuran; for 0.25h;

upstream raw materials:

4-iso-propylbromobenzene

N-(p-Brom-α,α-dimethylbenzyl)formamid

4-bromobenzenecarbonitrile

methyllithium

Downstream raw materials:

p-Brom-α,α-dimethylbenzylisocyanat

tert-butyl (2-(4-bromophenyl)propan-2-yl)carbamate

C₂₄H₂₆BrClN₄O₂

4-[4-(1-tertbutoxycarbonylamino-1-methylethyl)phenyl]-5-chloro-N-[4-(2-hydroxyethyl)phenyl]pyrimidine-2-amine

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