2-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenylamino)-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyrimidine-5-carbonitrile

Base Information

Chemical Name:2-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenylamino)-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyrimidine-5-carbonitrile
CAS No.:1356493-26-9
Molecular Formula:C₂₄H₂₉FN₁₀
Molecular Weight:476.56
Hs Code.:

Synonyms:2-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenylamino)-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyrimidine-5-carbonitrile

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Chemical Property of 2-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenylamino)-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyrimidine-5-carbonitrile

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Technology Process of 2-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenylamino)-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyrimidine-5-carbonitrile

There total 11 articles about 2-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenylamino)-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1309831-11-5
5-Cyano-2-Chloro-N₄-(2,2,6,6-Tetramethylpiperidin-4-yl)-4-Pyrimidineamine

: 1356493-51-0
4-cyclopropyl-2-fluoro-5-(1H-tetrazol-l-yl)benzeneamine

: 1356493-26-9
2-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenylamino)-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyrimidine-5-carbonitrile

Guidance literature:: 5-Cyano-2-Chloro-N₄-(2,2,6,6-Tetramethylpiperidin-4-yl)-4-Pyrimidineamine; 4-cyclopropyl-2-fluoro-5-(1H-tetrazol-l-yl)benzeneamine; With toluene-4-sulfonic acid; In isopropyl alcohol; at 80 ℃;

With ammonia; In methanol; isopropyl alcohol; at 20 ℃;

Reference yield:

: 1003-98-1
2-bromo-4-fluoroaniline

: 1356493-26-9
2-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenylamino)-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyrimidine-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / ethyl acetate / -30 - -20 °C

1.2: 1.08 h / -20 - -15 °C

2.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 100 °C / Inert atmosphere

3.1: trimethylsilylazide; acetic acid / 70 °C

3.2: pH 12 - 14

4.1: hydrogen / palladium 10% on activated carbon / ethanol; water; acetic acid / 1551.49 Torr

5.1: toluene-4-sulfonic acid / isopropyl alcohol / 80 °C

5.2: 20 °C

With trimethylsilylazide; sulfuric acid; hydrogen; caesium carbonate; toluene-4-sulfonic acid; acetic acid; tricyclohexylphosphine; palladium 10% on activated carbon; palladium diacetate; In ethanol; water; acetic acid; ethyl acetate; isopropyl alcohol; toluene;

Reference yield:

: 346433-97-4
2-bromo-4-fluoro-5-nitrophenylamine

: 1356493-26-9
2-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenylamino)-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyrimidine-5-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 100 °C / Inert atmosphere

2.1: trimethylsilylazide; acetic acid / 70 °C

2.2: pH 12 - 14

3.1: hydrogen / palladium 10% on activated carbon / ethanol; water; acetic acid / 1551.49 Torr

4.1: toluene-4-sulfonic acid / isopropyl alcohol / 80 °C

4.2: 20 °C

With trimethylsilylazide; hydrogen; caesium carbonate; toluene-4-sulfonic acid; acetic acid; tricyclohexylphosphine; palladium 10% on activated carbon; palladium diacetate; In ethanol; water; acetic acid; isopropyl alcohol; toluene;