3',5'-DICHLORO-2-PHENYLACETOPHENONE

Base Information

• Chemical Name: 3',5'-DICHLORO-2-PHENYLACETOPHENONE
• CAS No.: 845781-25-1
• Molecular Formula: C₁₄H₁₀Cl₂O
• Molecular Weight: 265.139
• Mol file: 845781-25-1.mol

Synonyms:1-(3,5-dichlorophenyl)-2-phenylethan-1-one

Chemical Property of 3',5'-DICHLORO-2-PHENYLACETOPHENONE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3',5'-DICHLORO-2-PHENYLACETOPHENONE ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3',5'-DICHLORO-2-PHENYLACETOPHENONE

There total 4 articles about 3',5'-DICHLORO-2-PHENYLACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

phenylacetic acid (103-82-2) + methyl 3,5-dichlorobenzoate (2905-67-1) → 1-(3,5-dichlorophenyl)-2-phenylethan-1-one (845781-25-1)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at -4 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c00235

Reference yield: 26.0%

2-(3,5-dichlorophenyl)-2-((trimethylsilyl)oxy)acetonitrile + benzyl bromide (100-39-0) → 1-(3,5-dichlorophenyl)-2-phenylethan-1-one (845781-25-1)

Guidance literature:

2-(3,5-dichlorophenyl)-2-((trimethylsilyl)oxy)acetonitrile; benzyl bromide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 24h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h;

DOI:10.1021/acs.jmedchem.9b00445

Reference yield: 19.4%

1-bromo-3,5-dichlorobenzene (19752-55-7) + N-methoxy-N-methyl-2-phenylacetamide (95092-10-7) → 1-(3,5-dichlorophenyl)-2-phenylethan-1-one (845781-25-1)

Guidance literature:

1-bromo-3,5-dichlorobenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

N-methoxy-N-methyl-2-phenylacetamide; In tetrahydrofuran; for 3h;

upstream raw materials:

1-bromo-3,5-dichlorobenzene

N-methoxy-N-methyl-2-phenylacetamide

3,5-dichlorobenzaldehyde

benzyl bromide

Downstream raw materials:

6-(3,5-dichlorophenyl)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one