methyl (R)-2-[(1s,4S)-4-(methylsulfonyloxy)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

Base Information

Chemical Name:methyl (R)-2-[(1s,4S)-4-(methylsulfonyloxy)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate
CAS No.:1372805-33-8
Molecular Formula:C₁₆H₂₂N₂O₉S₂
Molecular Weight:450.491
Hs Code.:

Synonyms:methyl (R)-2-[(1s,4S)-4-(methylsulfonyloxy)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (R)-2-[(1s,4S)-4-(methylsulfonyloxy)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

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Technology Process of methyl (R)-2-[(1s,4S)-4-(methylsulfonyloxy)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

There total 4 articles about methyl (R)-2-[(1s,4S)-4-(methylsulfonyloxy)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1372805-32-7
methyl (R)-2-[(1s,4S)-4-hydroxycyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

: 124-63-0
methanesulfonyl chloride

: 1372805-33-8
methyl (R)-2-[(1s,4S)-4-(methylsulfonyloxy)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

Guidance literature:: With triethylamine; In dichloromethane; at 5 - 20 ℃; for 1.5h; Inert atmosphere; Large scale reaction;
DOI:10.1055/s-0031-1289724

Reference yield:

: 22818-40-2
D-4-hydroxyphenylglycine

: 1372805-33-8
methyl (R)-2-[(1s,4S)-4-(methylsulfonyloxy)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetyl chloride / 19.5 h / 0 - 55 °C / Inert atmosphere; Large scale reaction

2.1: triethylamine / dichloromethane / 0.08 h / 25 °C / Large scale reaction

2.2: 20.75 h / 25 °C / Large scale reaction

3.1: Rh/Al₂O₃; hydrogen; acetic acid / 18 h / 35 °C / 3750.38 Torr

3.2: 2 h / 25 °C

4.1: triethylamine / dichloromethane / 1.5 h / 5 - 20 °C / Inert atmosphere; Large scale reaction

With Rh/Al₂O₃; hydrogen; acetic acid; triethylamine; acetyl chloride; In dichloromethane;
DOI:10.1055/s-0031-1289724

Reference yield:

: 57591-61-4,68697-60-9,127369-30-6,134694-94-3
methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride

: 1372805-33-8
methyl (R)-2-[(1s,4S)-4-(methylsulfonyloxy)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.08 h / 25 °C / Large scale reaction

1.2: 20.75 h / 25 °C / Large scale reaction

2.1: Rh/Al₂O₃; hydrogen; acetic acid / 18 h / 35 °C / 3750.38 Torr

2.2: 2 h / 25 °C

3.1: triethylamine / dichloromethane / 1.5 h / 5 - 20 °C / Inert atmosphere; Large scale reaction

With Rh/Al₂O₃; hydrogen; acetic acid; triethylamine; In dichloromethane;
DOI:10.1055/s-0031-1289724