1-[4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-ethanol

Base Information

Chemical Name:1-[4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-ethanol
CAS No.:604806-82-8
Molecular Formula:C₃₂H₃₅F₁₀NO₅Si
Molecular Weight:731.703
Hs Code.:

1-[4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-ethanol

Synonyms:1-[4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-ethanol

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Chemical Property of 1-[4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-ethanol

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Technology Process of 1-[4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-ethanol

There total 15 articles about 1-[4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 676-58-4
methylmagnesium chloride

: 604806-79-3
4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridine-3-carbaldehyde

: 604806-82-8
1-[4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-ethanol

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 0.25h;
DOI:10.1016/S0960-894X(02)00615-7

Reference yield:

: 4664-27-1
(4-methylpyridin-3-yl)methanol

: 604806-82-8
1-[4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 2 h / -78 - 20 °C

2.1: LDA; HMPA / tetrahydrofuran / 0.33 h / -78 °C

2.2: 76 percent / HMPA / tetrahydrofuran / 0.5 h / -78 - 0 °C

3.1: KHMDS; HMPA / tetrahydrofuran / 0.5 h / 20 °C

3.2: HMPA / tetrahydrofuran / 18 h / 55 °C

4.1: 2N aq. LiOH / tetrahydrofuran; methanol / 18 h / 50 °C

4.2: 4N aq. HCl

5.1: 89 percent / TBAF / tetrahydrofuran / 0.5 h / 0 °C

6.1: 98 percent / MnO₂ / CH₂Cl₂ / 17 h / 20 °C

7.1: 97 percent / CH₂Cl₂ / 0.25 h / 0 - 20 °C

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; manganese(IV) oxide; lithium hydroxide; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; 7.1: Grignard addition;
DOI:10.1016/S0960-894X(02)00615-7

Reference yield:

: 51227-28-2
4-methylnicotinaldehyde

: 604806-82-8
1-[4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-ethanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 47 percent / NaBH₄; MeOH / tetrahydrofuran / 1 h / 0 - 20 °C

2.1: 2,6-lutidine / CH₂Cl₂ / 2 h / -78 - 20 °C

3.1: LDA; HMPA / tetrahydrofuran / 0.33 h / -78 °C

3.2: 76 percent / HMPA / tetrahydrofuran / 0.5 h / -78 - 0 °C

4.1: KHMDS; HMPA / tetrahydrofuran / 0.5 h / 20 °C

4.2: HMPA / tetrahydrofuran / 18 h / 55 °C

5.1: 2N aq. LiOH / tetrahydrofuran; methanol / 18 h / 50 °C

5.2: 4N aq. HCl

6.1: 89 percent / TBAF / tetrahydrofuran / 0.5 h / 0 °C

7.1: 98 percent / MnO₂ / CH₂Cl₂ / 17 h / 20 °C

8.1: 97 percent / CH₂Cl₂ / 0.25 h / 0 - 20 °C

With 2,6-dimethylpyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; manganese(IV) oxide; lithium hydroxide; sodium tetrahydroborate; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; 8.1: Grignard addition;
DOI:10.1016/S0960-894X(02)00615-7