1-{6-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]pyridazin-3-yl}-5-methyl-1H-pyrazole-4-carboxylic acid

Base Information

Chemical Name:1-{6-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]pyridazin-3-yl}-5-methyl-1H-pyrazole-4-carboxylic acid
CAS No.:1404530-71-7
Molecular Formula:C₂₂H₂₅N₅O₅
Molecular Weight:439.471
Hs Code.:

Synonyms:1-{6-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]pyridazin-3-yl}-5-methyl-1H-pyrazole-4-carboxylic acid

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Chemical Property of 1-{6-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]pyridazin-3-yl}-5-methyl-1H-pyrazole-4-carboxylic acid

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Technology Process of 1-{6-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]pyridazin-3-yl}-5-methyl-1H-pyrazole-4-carboxylic acid

There total 4 articles about 1-{6-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]pyridazin-3-yl}-5-methyl-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1404530-70-6
1-[6-(4-methoxybenzylamino)pyridazin-3-yl]-5-methyl-1H-pyrazole-4-carboxylic acid

: 1404530-71-7
1-{6-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]pyridazin-3-yl}-5-methyl-1H-pyrazole-4-carboxylic acid

Guidance literature:: di-tert-butyl dicarbonate; 1-[6-(4-methoxybenzylamino)pyridazin-3-yl]-5-methyl-1H-pyrazole-4-carboxylic acid; With dmap; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

With potassium hydroxide; In water; N,N-dimethyl-formamide; for 20h;
DOI:10.1021/jm500588w

Reference yield:

: ethyl 1-(6-chloropyridazin-3-yl)-5-methyl-1H-pyrazole-4-carboxylate

: 1404530-71-7
1-{6-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]pyridazin-3-yl}-5-methyl-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,4-dioxane / 2 h / 130 °C

2.1: potassium hydroxide; water / ethanol / 2 h / 80 °C

3.1: dmap; triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C

3.2: 20 h

3.3: Aqueous phosphate buffer

With dmap; water; triethylamine; potassium hydroxide; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1404530-67-1
1-[6-(4-methoxybenzylamino)pyridazin-3-yl]-5-methyl-1Hpyrazole-4-carboxylic acid ethyl ester

: 1404530-71-7
1-{6-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]pyridazin-3-yl}-5-methyl-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide; water / ethanol / 2 h / 80 °C

2.1: dmap; triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C

2.2: 20 h

2.3: Aqueous phosphate buffer

With dmap; water; triethylamine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;