Ethyl 2-{1-[6-(4-methoxybenzylamino)-pyridazin-3-yl]-5-methyl-1H-pyrazole-4-carbonyl}butanoate

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Chemical Name:Ethyl 2-{1-[6-(4-methoxybenzylamino)-pyridazin-3-yl]-5-methyl-1H-pyrazole-4-carbonyl}butanoate
CAS No.:1404530-76-2
Molecular Formula:C₂₃H₂₇N₅O₄
Molecular Weight:437.498
Hs Code.:

Synonyms:Ethyl 2-{1-[6-(4-methoxybenzylamino)-pyridazin-3-yl]-5-methyl-1H-pyrazole-4-carbonyl}butanoate

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Chemical Property of Ethyl 2-{1-[6-(4-methoxybenzylamino)-pyridazin-3-yl]-5-methyl-1H-pyrazole-4-carbonyl}butanoate

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Technology Process of Ethyl 2-{1-[6-(4-methoxybenzylamino)-pyridazin-3-yl]-5-methyl-1H-pyrazole-4-carbonyl}butanoate

There total 6 articles about Ethyl 2-{1-[6-(4-methoxybenzylamino)-pyridazin-3-yl]-5-methyl-1H-pyrazole-4-carbonyl}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1404530-74-0
3-(1-{6-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]pyridazin-3-yl}-5-methyl-1H-pyrazol-4-yl)-3-oxopropionic acid ethyl ester

: 75-03-6
ethyl iodide

: 1404530-76-2
Ethyl 2-{1-[6-(4-methoxybenzylamino)-pyridazin-3-yl]-5-methyl-1H-pyrazole-4-carbonyl}butanoate

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; In tetrahydrofuran; at 55 ℃; for 20h;

Reference yield:

: ethyl 1-(6-chloropyridazin-3-yl)-5-methyl-1H-pyrazole-4-carboxylate

: 1404530-76-2
Ethyl 2-{1-[6-(4-methoxybenzylamino)-pyridazin-3-yl]-5-methyl-1H-pyrazole-4-carbonyl}butanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-dioxane / 2 h / 130 °C

2.1: potassium hydroxide; water / ethanol / 2 h / 80 °C

3.1: dmap; triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C

3.2: 20 h

3.3: Aqueous phosphate buffer

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 h / 20 °C

4.2: 20 h / 55 °C

5.1: potassium carbonate; tetrabutylammomium bromide / tetrahydrofuran / 20 h / 55 °C

With dmap; tetrabutylammomium bromide; water; potassium carbonate; triethylamine; 1,1'-carbonyldiimidazole; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1404530-70-6
1-[6-(4-methoxybenzylamino)pyridazin-3-yl]-5-methyl-1H-pyrazole-4-carboxylic acid

: 1404530-76-2
Ethyl 2-{1-[6-(4-methoxybenzylamino)-pyridazin-3-yl]-5-methyl-1H-pyrazole-4-carbonyl}butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C

1.2: 20 h

1.3: Aqueous phosphate buffer

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 h / 20 °C

2.2: 20 h / 55 °C

3.1: potassium carbonate; tetrabutylammomium bromide / tetrahydrofuran / 20 h / 55 °C

With dmap; tetrabutylammomium bromide; potassium carbonate; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; N,N-dimethyl-formamide;