(3S,4R)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-3-[2,3,3,3-tetrafluoro-2-(trifluoromethyl)propyl]-2-pyrrolidinone

Base Information

Chemical Name:(3S,4R)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-3-[2,3,3,3-tetrafluoro-2-(trifluoromethyl)propyl]-2-pyrrolidinone
CAS No.:1345966-28-0
Molecular Formula:C₁₇H₁₇F₇INO₂
Molecular Weight:527.221
Hs Code.:

Synonyms:(3S,4R)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-3-[2,3,3,3-tetrafluoro-2-(trifluoromethyl)propyl]-2-pyrrolidinone

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Chemical Property of (3S,4R)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-3-[2,3,3,3-tetrafluoro-2-(trifluoromethyl)propyl]-2-pyrrolidinone

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Technology Process of (3S,4R)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-3-[2,3,3,3-tetrafluoro-2-(trifluoromethyl)propyl]-2-pyrrolidinone

There total 9 articles about (3S,4R)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-3-[2,3,3,3-tetrafluoro-2-(trifluoromethyl)propyl]-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 914498-71-8
N-(phenylmethoxy)-2-methyl-N-(2-propen-1-yl)-2-propenamide

: 677-69-0
perfluoroisopropyl iodide

: 1345966-28-0
(3S,4R)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-3-[2,3,3,3-tetrafluoro-2-(trifluoromethyl)propyl]-2-pyrrolidinone

: cis-3-(iodomethyl)-3-methyl-1-(phenylmethoxy)-4-[2,3,3,3-tetrafluoro-2-(trifluoromethyl)propyl]-2-pyrrolidinone

Guidance literature:: N-(phenylmethoxy)-2-methyl-N-(2-propen-1-yl)-2-propenamide; With (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

perfluoroisopropyl iodide; With triethyl borane; In hexane; dichloromethane; at -78 ℃; for 120h; enantioselective reaction;
DOI:10.1021/jo3015227

Reference yield:

: 914498-71-8
N-(phenylmethoxy)-2-methyl-N-(2-propen-1-yl)-2-propenamide

: 677-69-0
perfluoroisopropyl iodide

: 1345966-28-0
(3S,4R)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-3-[2,3,3,3-tetrafluoro-2-(trifluoromethyl)propyl]-2-pyrrolidinone

: (3S,4S)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-3-[2,3,3,3-tetrafluoro-2-(trifluoromethyl)propyl]-2-pyrrolidinone

: cis-3-(iodomethyl)-3-methyl-1-(phenylmethoxy)-4-[2,3,3,3-tetrafluoro-2-(trifluoromethyl)propyl]-2-pyrrolidinone

Guidance literature:: N-(phenylmethoxy)-2-methyl-N-(2-propen-1-yl)-2-propenamide; With (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

perfluoroisopropyl iodide; With triethyl borane; In hexane; dichloromethane; at -78 ℃; for 2.5h; Overall yield = 77 %; regioselective reaction;
DOI:10.1021/jo3015227

Reference yield:

: 122148-92-9
N-(phenylmethoxy)-N-2-propenylcarbamic acid 1,1-dimethylethyl ester

: 1345966-28-0
(3S,4R)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-3-[2,3,3,3-tetrafluoro-2-(trifluoromethyl)propyl]-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.1: (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.2: 120 h / -78 °C

With (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo3015227