6-(2-bromophenyl)-N-ethyl-8-fluoro-4H-imidazo-[1,5-a][1,4]benzodiazepine-3-carboxamide

Base Information

Chemical Name:6-(2-bromophenyl)-N-ethyl-8-fluoro-4H-imidazo-[1,5-a][1,4]benzodiazepine-3-carboxamide
CAS No.:153874-01-2
Molecular Formula:C₂₀H₁₆BrFN₄O
Molecular Weight:427.276
Hs Code.:

Synonyms:6-(2-bromophenyl)-N-ethyl-8-fluoro-4H-imidazo-[1,5-a][1,4]benzodiazepine-3-carboxamide

Suppliers and Price of 6-(2-bromophenyl)-N-ethyl-8-fluoro-4H-imidazo-[1,5-a][1,4]benzodiazepine-3-carboxamide

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Chemical Property of 6-(2-bromophenyl)-N-ethyl-8-fluoro-4H-imidazo-[1,5-a][1,4]benzodiazepine-3-carboxamide

Chemical Property:

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Technology Process of 6-(2-bromophenyl)-N-ethyl-8-fluoro-4H-imidazo-[1,5-a][1,4]benzodiazepine-3-carboxamide

There total 5 articles about 6-(2-bromophenyl)-N-ethyl-8-fluoro-4H-imidazo-[1,5-a][1,4]benzodiazepine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 497-19-8
sodium carbonate

: 75-04-7,85404-22-4
ethylamine

: 153874-00-1
6-(2-bromophenyl)-8-fluoro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid

: 153874-01-2
6-(2-bromophenyl)-N-ethyl-8-fluoro-4H-imidazo-[1,5-a][1,4]benzodiazepine-3-carboxamide

Guidance literature:: With phosphorus pentachloride; In dichloromethane;

Reference yield:

: 153873-94-0
(2-amino-5-fluorophenyl)(2-bromophenyl)methanone

: 153874-01-2
6-(2-bromophenyl)-N-ethyl-8-fluoro-4H-imidazo-[1,5-a][1,4]benzodiazepine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / tetrahydrofuran / 24 h

2: 71 percent / NH₂NH₂*H₂O / methanol / 24 h

3: 1.) potassium tert-butoxide, diethyl chlorophosphate / 1.) THF, from -20 deg C to 10 deg C, 2.) THF, from -20 deg C to RT, 1.5 h

4: 90 percent / 6 N HCl / 24 h / 90 °C

5: 1.) PCl₅ / 1.) CH₂Cl₂, RT, 2 h, 2.) CH₂Cl₂, 15 min

With hydrogenchloride; phosphorus pentachloride; potassium tert-butylate; diethyl chlorophosphate; hydrazine hydrate; In tetrahydrofuran; methanol;
DOI:10.1002/(SICI)1099-1344(199612)38:12<1121::AID-JLCR948>3.0.CO;2-V

Reference yield:

: 186351-08-6
N-[2-(2-Bromo-benzoyl)-4-fluoro-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide

: 153874-01-2
6-(2-bromophenyl)-N-ethyl-8-fluoro-4H-imidazo-[1,5-a][1,4]benzodiazepine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / NH₂NH₂*H₂O / methanol / 24 h

2: 1.) potassium tert-butoxide, diethyl chlorophosphate / 1.) THF, from -20 deg C to 10 deg C, 2.) THF, from -20 deg C to RT, 1.5 h

3: 90 percent / 6 N HCl / 24 h / 90 °C

4: 1.) PCl₅ / 1.) CH₂Cl₂, RT, 2 h, 2.) CH₂Cl₂, 15 min

With hydrogenchloride; phosphorus pentachloride; potassium tert-butylate; diethyl chlorophosphate; hydrazine hydrate; In methanol;
DOI:10.1002/(SICI)1099-1344(199612)38:12<1121::AID-JLCR948>3.0.CO;2-V