ethyl 2-[2-[2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate

Base Information

• Chemical Name: ethyl 2-[2-[2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate
• CAS No.: 288590-38-5
• Molecular Formula: C₃₇H₂₈N₈O₅S₄
• Molecular Weight: 792.944
• Mol file: 288590-38-5.mol

Synonyms:ethyl 2-[2-[2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate

Chemical Property of ethyl 2-[2-[2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[2-[2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate

There total 9 articles about ethyl 2-[2-[2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-({2-[(2-amino-thiazole-4-carbonyl)-amino]-thiazole-4-carbonyl}-amino)-thiazole-4-carboxylic acid ethyl ester + 1,2,3-benzotriazol-1-yl 2-triphenylmethylamino-1,3-thiazole-4-carboxylate (288590-32-9) → ethyl 2-[2-[2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate (288590-38-5)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 17h;

DOI:10.1016/S0968-0896(00)00029-8

Reference yield:

2-[(2-amino-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid ethyl ester → ethyl 2-[2-[2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate (288590-38-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / NEt₃ / dimethylformamide / 17 h / 50 °C

2: 0.51 g / TFA / CHCl₃ / 1 h / 20 °C

3: 48 percent / NEt₃ / dimethylformamide / 17 h / 50 °C

With triethylamine; trifluoroacetic acid; In chloroform; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(00)01181-8

Reference yield:

ethyl 2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate (288590-36-3) → ethyl 2-[2-[2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate (288590-38-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.03 g / TFA / CHCl₃ / 1 h / 20 °C

2: 55 percent / NEt₃ / dimethylformamide / 17 h / 50 °C

3: 0.51 g / TFA / CHCl₃ / 1 h / 20 °C

4: 48 percent / NEt₃ / dimethylformamide / 17 h / 50 °C

With triethylamine; trifluoroacetic acid; In chloroform; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(00)01181-8

upstream raw materials:

1,2,3-benzotriazol-1-yl 2-triphenylmethylamino-1,3-thiazole-4-carboxylate

2-aminothiazole-4-carboxylate

trityl chloride

ethyl 2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate

Downstream raw materials:

2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid ethyl ester

2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid

C₄₆H₄₇N₁₁O₅S₄

C₄₄H₄₂N₁₀O₇S₄