4-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrrole-2-carboxylic acid

Base Information

Chemical Name:4-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrrole-2-carboxylic acid
CAS No.:1413064-13-7
Molecular Formula:C₂₄H₂₃N₃O₄
Molecular Weight:417.464
Hs Code.:

Synonyms:4-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrrole-2-carboxylic acid

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Chemical Property of 4-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrrole-2-carboxylic acid

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Technology Process of 4-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrrole-2-carboxylic acid

There total 5 articles about 4-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1413064-08-0
4-[2-acetoxymethyl-3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-phenyl]-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 1413064-13-7
4-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrrole-2-carboxylic acid

Guidance literature:: 4-[2-acetoxymethyl-3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-phenyl]-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester; With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 20h;

With hydrogenchloride; water; pH=3 - 4;

Reference yield:

: 69321-60-4
2,6-dibromotoluene

: 1413064-13-7
4-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 20 h / Reflux

2.1: N,N-dimethyl-formamide / 6 h / 105 °C

3.1: caesium carbonate / copper(l) iodide; N,N-dimethylethylenediamine / N,N-dimethyl-formamide / 4 h / 150 °C / Inert atmosphere

4.1: potassium carbonate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

5.1: sodium hydroxide; water / 1,4-dioxane / 20 h / 20 °C

5.2: pH 3 - 4

With N-Bromosuccinimide; water; potassium carbonate; caesium carbonate; sodium hydroxide; copper(l) iodide; N,N-dimethylethylenediamine; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 93701-32-7
2,6-dibromobenzyl bromide

: 1413064-13-7
4-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 6 h / 105 °C

2.1: caesium carbonate / copper(l) iodide; N,N-dimethylethylenediamine / N,N-dimethyl-formamide / 4 h / 150 °C / Inert atmosphere

3.1: potassium carbonate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

4.1: sodium hydroxide; water / 1,4-dioxane / 20 h / 20 °C

4.2: pH 3 - 4

With water; potassium carbonate; caesium carbonate; sodium hydroxide; copper(l) iodide; N,N-dimethylethylenediamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;