3-Amino-4-methoxybenzanilide

Base Information

• Chemical Name: 3-Amino-4-methoxybenzanilide
• CAS No.: 120-35-4
• Molecular Formula: C14H14N2O2
• Molecular Weight: 242.277
• Hs Code.: 2924299090
• European Community (EC) Number: 204-388-4
• NSC Number: 50647
• UNII: V5Y646AW8S
• DSSTox Substance ID: DTXSID0051607
• Nikkaji Number: J5.324D
• Wikidata: Q27291569
• Mol file: 120-35-4.mol

Synonyms:3-Amino-4-methoxybenzanilide;120-35-4;3-Amino-4-methoxy-N-phenylbenzamide;3-Amino-p-anisanilide;Benzamide, 3-amino-4-methoxy-N-phenyl-;p-Anisanilide, 3-amino-;3-Amino-4-methoxy benzanilide;BENZANILIDE, 3-AMINO-4-METHOXY-;EINECS 204-388-4;NSC 50647;3-Amino-4-methoxy-N-phenyl-benzamide;UNII-V5Y646AW8S;V5Y646AW8S;MFCD00017166;NSC-50647;EC 204-388-4;NSC50647;WLN: 1OR BZ DVMR;Cambridge id 5301790;Oprea1_563744;SCHEMBL610530;3-amino-4-methoxy-benzanilide;DTXSID0051607;LHMQDVIHBXWNII-UHFFFAOYSA-;3-AMINO-4-METHOXYBENZANILID;AC8086;BBL027830;STK804189;4-methoxy-3-amino-N-phenyl-benzamide;AKOS000132022;3-amino-4 -methoxy-N-phenyl-benzamide;3-amino-4-methoxy-n'-phenyl benzamide;AM84353;Benzamida, 3-amino-4-metoxi-N-fenil-;CS-W012775;3-Amino-4-methoxy-N-phenylbenzamide #;AS-63529;LS-27602;SY016941;BB 0242920;FT-0614982;AB00079390-01;W-108478;Q27291569

Chemical Property of 3-Amino-4-methoxybenzanilide

Chemical Property:

• Appearance/Colour: white or light yellow powder
• Vapor Pressure: 1.67E-05mmHg at 25°C
• Melting Point: 154-156 °C
• Refractive Index: 1.658
• Boiling Point: 364.5 °C at 760 mmHg
• PKA: 13.44±0.70(Predicted)
• Flash Point: 174.3 °C
• PSA: 64.35000
• Density: 1.245 g/cm³
• LogP: 3.18390
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 242.105527694
• Heavy Atom Count: 18
• Complexity: 277

Purity/Quality:

99%min ^*data from raw suppliers

3-Amino-4-methoxybenzanilide >98.0%(T) ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2)N
• Uses: 3-Amino-4-methoxybenzanilide is used in preparation method of Cyanate resin-based near-zero expansion composite material truss rod. Dyes, pharmaceuticals, and other organic chemicals.

Technology Process of 3-Amino-4-methoxybenzanilide

There total 9 articles about 3-Amino-4-methoxybenzanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.55%

4-methoxy-3-nitrobenzoic acid (89-41-8) + aniline (62-53-3) → 3-amino-4-methoxybenzoic acid phenylamide (120-35-4)

Guidance literature:

4-methoxy-3-nitrobenzoic acid; aniline; In toluene; at 132 - 140 ℃; for 8.5h;

With palladium on activated charcoal; hydrogen; In water; at 88 - 91 ℃; for 4h; Temperature;

Reference yield: 95.3%

3-nitro-4-methoxybenzanilide (97-32-5) → 3-amino-4-methoxybenzoic acid phenylamide (120-35-4)

Guidance literature:

With iron(II) oxide; hydrazine hydrate; In methanol; water; at 55 - 60 ℃; for 3h; Reagent/catalyst; Temperature; Solvent; Reflux; Large scale; Green chemistry;

Reference yield: 93.8%

(4-methoxy-3-nitrophenyl)methanol (41870-24-0) + aniline (62-53-3) → 3-amino-4-methoxybenzoic acid phenylamide (120-35-4)

Guidance literature:

(4-methoxy-3-nitrophenyl)methanol; aniline; With ammonium cerium (IV) nitrate; zirconocene dichloride; 1-(diphenylphosphino)ferrocene-1-(di-tert-butylphosphino)ferrocene; 1,3-bis(mesityl)imidazolium chloride; In benzonitrile; at 80 ℃; for 10h;

With sodium sulfide; water; In benzonitrile; at 80 ℃; for 14h; Reagent/catalyst; Solvent; Temperature;

upstream raw materials:

benzoyl chloride

1-chloro-2,4-dinitro-benzene

N-[2-methoxy-5-chlorophenyl]-3-hydroxy-2-naphthalene carboxamide

3-amino-4-methoxybenzoic acid

Downstream raw materials:

4-Methoxy-3-(3,5-dimethyl-benzylamino)-N-phenyl-benzamide

Refernces

• 1、 -. "Preparation method of 3-amino-4-methoxybenzaniline". . . Retrieved 2016/10/17.
• 2、 Ji, Xing-Yue,Wang, Hui-Qiang,Hao, Lan-Hu,He, Wei-Ying,Gao, Rong-Mei,Li, Yan-Ping,Li, Yu-Huan,Jiang, Jian-Dong,Li, Zhuo-Rong. "Synthesis and antiviral activity of N-phenylbenzamide derivatives, a novel class of enterovirus 71 inhibitors". . p. 3630 - 3640. Retrieved 2013/05/09.