4-{4-[4-(3-methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:4-{4-[4-(3-methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid methyl ester
CAS No.:1195972-61-2
Molecular Formula:C₂₄H₃₀N₄O₅S
Molecular Weight:486.592
Hs Code.:

Synonyms:4-{4-[4-(3-methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid methyl ester

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Chemical Property of 4-{4-[4-(3-methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid methyl ester

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Technology Process of 4-{4-[4-(3-methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid methyl ester

There total 6 articles about 4-{4-[4-(3-methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1195972-63-4
1-(2-chloro-pyrimidin-4-yl)-4-(3-methanesulfonyl-propoxy)-1H-indole

: 61367-07-5,61367-16-6,100707-54-8
trans-4-aminocyclohexylcarboxylic acid methyl ester hydrochloride

: 1195972-61-2
4-{4-[4-(3-methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid methyl ester

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 20 - 80 ℃;

Reference yield: 90.0%

: 1-(2-methanesulfinyl-pyrimidin-4-yl)-4-(3-methanesulfonyl-propoxy)-1H-indole

: 62456-15-9
methyl trans-4-amino-cyclohexanecarboxylate

: 1195972-61-2
4-{4-[4-(3-methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid methyl ester

Guidance literature:: In N,N-dimethyl acetamide; at 120 ℃; for 4h;

Reference yield:

: 1195972-67-8
4-(3-methylsulfanyl-propoxy)-1H-indole

: 1195972-61-2
4-{4-[4-(3-methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 - 40 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane; methanol / 1.83 h / -5 - 2 °C

3: N,N-dimethyl acetamide / 4 h / 120 °C

With potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide;