2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-((trimethylsilyl)oxy)acetonitrile

Base Information

Chemical Name:2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-((trimethylsilyl)oxy)acetonitrile
CAS No.:1418717-70-0
Molecular Formula:C₂₇H₂₈FN₃OSi
Molecular Weight:457.623
Hs Code.:

Synonyms:2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-((trimethylsilyl)oxy)acetonitrile

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Chemical Property of 2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-((trimethylsilyl)oxy)acetonitrile

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Technology Process of 2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-((trimethylsilyl)oxy)acetonitrile

There total 8 articles about 2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-((trimethylsilyl)oxy)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 1418717-63-1
1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

: 1418717-70-0
2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-((trimethylsilyl)oxy)acetonitrile

Guidance literature:: With zinc(II) iodide; In dichloromethane; at 20 ℃; for 1h; under 760.051 Torr; Cooling with ice;

Reference yield:

: 1418717-44-8
3-ethyl 5-methyl 2-amino-6-methyl-4-(p-tolyl)-1,4-dihydropyridine-3,5-dicarboxylate

: 1418717-70-0
2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-((trimethylsilyl)oxy)acetonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1.5 h / 20 °C / 760.05 Torr

2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1 h / 0 °C / 760.05 Torr

3: pyridinium chlorochromate / dichloromethane / 24 h / 20 °C / 760.05 Torr

4: caesium carbonate / methanol; hexane / 1 h / 60 °C / 760.05 Torr

5: caesium carbonate / acetonitrile / 1.5 h / 70 °C / 760.05 Torr

6: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / 760.05 Torr / Cooling with ice

7: pyridinium chlorochromate / dichloromethane / 18 h / 20 °C / 760.05 Torr

8: zinc(II) iodide / dichloromethane / 1 h / 20 °C / 760.05 Torr / Cooling with ice

With lithium aluminium tetrahydride; caesium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc(II) iodide; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1418717-47-1
3-ethyl 5-methyl 2-amino-6-methyl-4-(p-tolyl)pyridine-3,5-dicarboxylate

: 1418717-70-0
2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-((trimethylsilyl)oxy)acetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1 h / 0 °C / 760.05 Torr

2: pyridinium chlorochromate / dichloromethane / 24 h / 20 °C / 760.05 Torr

3: caesium carbonate / methanol; hexane / 1 h / 60 °C / 760.05 Torr

4: caesium carbonate / acetonitrile / 1.5 h / 70 °C / 760.05 Torr

5: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / 760.05 Torr / Cooling with ice

6: pyridinium chlorochromate / dichloromethane / 18 h / 20 °C / 760.05 Torr

7: zinc(II) iodide / dichloromethane / 1 h / 20 °C / 760.05 Torr / Cooling with ice

With lithium aluminium tetrahydride; caesium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; zinc(II) iodide; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene; acetonitrile;