methyl 2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

Base Information

Chemical Name:methyl 2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate
CAS No.:1418717-66-4
Molecular Formula:C₂₅H₂₃FN₂O₃
Molecular Weight:418.468
Hs Code.:

Synonyms:methyl 2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

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Chemical Property of methyl 2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

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Technology Process of methyl 2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

There total 10 articles about methyl 2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1418717-70-0
2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-((trimethylsilyl)oxy)acetonitrile

: 1418717-66-4
methyl 2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

Guidance literature:: With sulfuric acid; for 18h; under 760.051 Torr; Cooling with ice; Reflux;

Reference yield:

: 1418717-44-8
3-ethyl 5-methyl 2-amino-6-methyl-4-(p-tolyl)-1,4-dihydropyridine-3,5-dicarboxylate

: 1418717-66-4
methyl 2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 9 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1.5 h / 20 °C / 760.05 Torr

2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1 h / 0 °C / 760.05 Torr

3: pyridinium chlorochromate / dichloromethane / 24 h / 20 °C / 760.05 Torr

4: caesium carbonate / methanol; hexane / 1 h / 60 °C / 760.05 Torr

5: caesium carbonate / acetonitrile / 1.5 h / 70 °C / 760.05 Torr

6: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / 760.05 Torr / Cooling with ice

7: pyridinium chlorochromate / dichloromethane / 18 h / 20 °C / 760.05 Torr

8: zinc(II) iodide / dichloromethane / 1 h / 20 °C / 760.05 Torr / Cooling with ice

9: sulfuric acid / 18 h / 760.05 Torr / Cooling with ice; Reflux

With lithium aluminium tetrahydride; sulfuric acid; caesium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc(II) iodide; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1418717-47-1
3-ethyl 5-methyl 2-amino-6-methyl-4-(p-tolyl)pyridine-3,5-dicarboxylate

: 1418717-66-4
methyl 2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 8 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1 h / 0 °C / 760.05 Torr

2: pyridinium chlorochromate / dichloromethane / 24 h / 20 °C / 760.05 Torr

3: caesium carbonate / methanol; hexane / 1 h / 60 °C / 760.05 Torr

4: caesium carbonate / acetonitrile / 1.5 h / 70 °C / 760.05 Torr

5: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / 760.05 Torr / Cooling with ice

6: pyridinium chlorochromate / dichloromethane / 18 h / 20 °C / 760.05 Torr

7: zinc(II) iodide / dichloromethane / 1 h / 20 °C / 760.05 Torr / Cooling with ice

8: sulfuric acid / 18 h / 760.05 Torr / Cooling with ice; Reflux

With lithium aluminium tetrahydride; sulfuric acid; caesium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; zinc(II) iodide; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene; acetonitrile;