Disodium 4-nitrophenylphosphate

Base Information

• Chemical Name: Disodium 4-nitrophenylphosphate
• CAS No.: 4264-83-9
• Molecular Formula: C6H4NNa2O6P
• Molecular Weight: 263.054
• Hs Code.: 29199000
• Mol file: 4264-83-9.mol

Synonyms:Phenol,p-nitro-, di-H phosphate, disodium salt (7CI);Phenol, p-nitro-, phosphatedisodium salt (6CI);Phosphoric acid, mono(4-nitrophenyl) ester, disodium salt(9CI);4-Nitrophenyl phosphate disodium salt;Disodium mono(4-nitrophenyl) phosphate;Disodium p-nitrophenyl phosphate;p-NPPdisodium salt;p-Nitrophenyl disodium phosphate;p-Nitrophenyl phosphatedisodium salt;PNPP;4-Nitrophenyl phosphate, disodium salt;Disodium 4-nitrophenylphosphate;

Chemical Property of Disodium 4-nitrophenylphosphate

Chemical Property:

• Appearance/Colour: White crystalline
• Vapor Pressure: 15Pa at 20-50℃
• Melting Point: >300 °C(lit.)
• Boiling Point: 457.849 °C at 760 mmHg
• Flash Point: 230.699 °C
• PSA: 128.05000
• Density: 1.712g/cm3
• LogP: 2.46590
• Storage Temp.: 2-8°C
• Solubility.: H2O: 1 tablet/3 mL 25 mM, clear, light yellow
• Water Solubility.: Miscible with water. Immiscible with ethanol and acetone.

Purity/Quality:

99% ^*data from raw suppliers

PNPP,DisodiumHexahydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/38-36/37/38-48/22-41-38-21/22
• Safety Statements: 26-36-24/25-23-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: PNPP, Disodium Salt is a colorimetric alkaline phosphatase soluble substrate, p-Nitrophenyl Phosphate (pNPP) is the substrate of choice for use with alkaline phosphatase in Enzyme Linked Immunosorbant Assay (ELISA) procedures.

Technology Process of Disodium 4-nitrophenylphosphate

There total 7 articles about Disodium 4-nitrophenylphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

sodium bis(4-nitrophenyl) phosphate (4043-96-3) → disodium (4-nitrophenyl)phosphate (4264-83-9)

Guidance literature:

{[Cu{[(1-vinylIm-2-yl)CH₂]3N}Cl]PF₆}-{[CH₂=C(CH₃)CO₂CH₂-]n}; In water; dimethyl sulfoxide; at 50 ℃; for 96h; pH=9.5; Further Variations:; Catalysts; pH-values; Temperatures; catalyst ratios; Kinetics;

DOI:10.1039/b605676h

Reference yield:

sodium bis(4-nitrophenyl) phosphate (4043-96-3) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + disodium (4-nitrophenyl)phosphate (4264-83-9)

Guidance literature:

With [D]-sodium hydroxide; (Et₂NH₂)₈[{α-PW₁₁O₃₉Zr(μ-OH)(H₂O)}₂]*7H₂O; sodium diphenyl phosphate; hydrogen chloride; In water-d2; at 60 ℃; pH=6.4; Reagent/catalyst; Temperature; Concentration; Kinetics;

DOI:10.1002/ejic.201402735

Reference yield:

mono-p-nitrophenyl phosphate (330-13-2) → disodium (4-nitrophenyl)phosphate (4264-83-9)

Guidance literature:

With sodium hydroxide; In water; at 0 ℃; Cooling with ice;

upstream raw materials:

sodium bis(4-nitrophenyl) phosphate

4-nitro-phenol

paraoxon

mono-p-nitrophenyl phosphate

Downstream raw materials:

Tentraethylammonium 4-nitrophenoxide

4-nitro-phenol

4-nitrophenol sodium salt

bis-sodium salt of methyl phosphate

Refernces

• 1、 -. "P-nitrophenyl phosphate disodium and preparation method thereof". . . Retrieved 2020/01/12.
• 2、 Martin, Marco,Gasparini, Giulio,Graziani, Matteo,Prins, Leonard J.,Scrimin, Paolo. "The advantage of covalent capture in the combinatorial screening of a dynamic library for the detection of weak interactions". scheme or table. p. 3858 - 3866. Retrieved 2010/09/05.