fluoren-9-ylmethyl 4-(tert-butyldimethylsilanyloxy)-5-(tert-butyldimethylsilanyloxymethyl)-2-[2-(2-phenoxyacetylamino)pyridin-5-yl]pyrrolidine-1-carboxylate

Base Information

Chemical Name:fluoren-9-ylmethyl 4-(tert-butyldimethylsilanyloxy)-5-(tert-butyldimethylsilanyloxymethyl)-2-[2-(2-phenoxyacetylamino)pyridin-5-yl]pyrrolidine-1-carboxylate
CAS No.:954127-72-1
Molecular Formula:C₄₅H₅₉N₃O₆Si₂
Molecular Weight:794.151
Hs Code.:

fluoren-9-ylmethyl 4-(tert-butyldimethylsilanyloxy)-5-(tert-butyldimethylsilanyloxymethyl)-2-[2-(2-phenoxyacetylamino)pyridin-5-yl]pyrrolidine-1-carboxylate

Synonyms:fluoren-9-ylmethyl 4-(tert-butyldimethylsilanyloxy)-5-(tert-butyldimethylsilanyloxymethyl)-2-[2-(2-phenoxyacetylamino)pyridin-5-yl]pyrrolidine-1-carboxylate

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Chemical Property of fluoren-9-ylmethyl 4-(tert-butyldimethylsilanyloxy)-5-(tert-butyldimethylsilanyloxymethyl)-2-[2-(2-phenoxyacetylamino)pyridin-5-yl]pyrrolidine-1-carboxylate

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Technology Process of fluoren-9-ylmethyl 4-(tert-butyldimethylsilanyloxy)-5-(tert-butyldimethylsilanyloxymethyl)-2-[2-(2-phenoxyacetylamino)pyridin-5-yl]pyrrolidine-1-carboxylate

There total 12 articles about fluoren-9-ylmethyl 4-(tert-butyldimethylsilanyloxy)-5-(tert-butyldimethylsilanyloxymethyl)-2-[2-(2-phenoxyacetylamino)pyridin-5-yl]pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 954127-71-0
fluoren-9-ylmethyl 2-(2-aminopyridin-5-yl)-4-(tert-butyldimethylsilanyloxy)-5-(tert-butyldimethylsilanyloxymethyl)pyrrolidine-1-carboxylate

: 14316-61-1
phenoxyacetic anhydride

: 954127-72-1
fluoren-9-ylmethyl 4-(tert-butyldimethylsilanyloxy)-5-(tert-butyldimethylsilanyloxymethyl)-2-[2-(2-phenoxyacetylamino)pyridin-5-yl]pyrrolidine-1-carboxylate

Guidance literature:: With pyridine; at 20 ℃; for 2h;
DOI:10.1002/ejoc.200700217

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 954127-72-1
fluoren-9-ylmethyl 4-(tert-butyldimethylsilanyloxy)-5-(tert-butyldimethylsilanyloxymethyl)-2-[2-(2-phenoxyacetylamino)pyridin-5-yl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: nBuLi / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: tetrahydrofuran; hexane / 1.5 h / -78 °C

1.3: 79 percent / nBuLi / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

2.1: nBuLi / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 19 percent / tetrahydrofuran; hexane / 2 h / -78 °C

3.1: 75 percent / aq. NaHCO₃ / tetrahydrofuran; dioxane / 0.5 h / 20 °C

4.1: 99 percent / pyridine / 2 h / 20 °C

With pyridine; n-butyllithium; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; hexane;
DOI:10.1002/ejoc.200700217

Reference yield:

: 954127-70-9
2-(2-aminopyridin-5-yl)-4-(tert-butyldimethylsilanyloxy)-5-(tert-butyldimethylsilanyloxymethyl)pyrrolidine

: 954127-72-1
fluoren-9-ylmethyl 4-(tert-butyldimethylsilanyloxy)-5-(tert-butyldimethylsilanyloxymethyl)-2-[2-(2-phenoxyacetylamino)pyridin-5-yl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / aq. NaHCO₃ / tetrahydrofuran; dioxane / 0.5 h / 20 °C

2: 99 percent / pyridine / 2 h / 20 °C

With pyridine; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1002/ejoc.200700217