2-<2-(1,3-dithian-2-yl)-1-phenylethyl>-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one

Base Information

• Chemical Name: 2-<2-(1,3-dithian-2-yl)-1-phenylethyl>-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one
• CAS No.: 111222-90-3
• Molecular Formula: C₂₉H₃₀O₅S₂
• Molecular Weight: 522.686

Synonyms:2-<2-(1,3-dithian-2-yl)-1-phenylethyl>-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one

Chemical Property of 2-<2-(1,3-dithian-2-yl)-1-phenylethyl>-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one

Chemical Property:

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Technology Process of 2-<2-(1,3-dithian-2-yl)-1-phenylethyl>-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one

There total 9 articles about 2-<2-(1,3-dithian-2-yl)-1-phenylethyl>-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one (117828-33-8) + 2-(2-Iodo-2-phenyl-ethyl)-[1,3]dithiane (111222-94-7) → 2-<2-(1,3-dithian-2-yl)-1-phenylethyl>-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one (111222-90-3) + 3-(2-[1,3]Dithian-2-yl-1-phenyl-ethoxy)-4,6-dimethoxy-2-(4-methoxy-phenyl)-benzofuran (111222-89-0)

Guidance literature:

With sodium hydride; In toluene; for 1h; Heating;

Reference yield:

4,6-dihydroxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one (117828-32-7) → 2-<2-(1,3-dithian-2-yl)-1-phenylethyl>-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one (111222-90-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) HCl, methanol

2: 1.) K₂CO₃

With hydrogenchloride; methanol; potassium carbonate;

DOI:10.1039/c39870000025

Reference yield:

3,5-dihydroxyphenol (108-73-6) → 2-<2-(1,3-dithian-2-yl)-1-phenylethyl>-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one (111222-90-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) HCl(g), 2) 0.1 M aq. HCl / 1) 0 deg C, 1 h, 2) reflux, 3 h

2: 1) K₂CO₃, 2) 5percent aq. HCl / 1) (CH₃)2CO, reflux, 30 min, 2) MeOH, reflux, 3 h

3: K₂CO₃ / toluene / 1 h / Heating

With hydrogenchloride; potassium carbonate; In toluene;

upstream raw materials:

4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one

2-(2-Iodo-2-phenyl-ethyl)-[1,3]dithiane

styrene oxide

2-(2-hydroxy-2-phenylethyl)-1,3-dithiane

Downstream raw materials:

3-Butyl-2-(2-[1,3]dithian-2-yl-1-phenyl-ethyl)-4,6-dimethoxy-2-(4-methoxy-phenyl)-2,3-dihydro-benzofuran-3-ol

8b-hydroxy-6,8-dimethoxy-3a(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopentabenzofuran-1-spiro-2'-(1',3'-dithiane)

3-<4,6-dimethoxy-2-(4-methoxyphenyl)-3-oxo-2,3-dihydrobenzofuran-2-yl>-3-phenylpropanal

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