4-(tert-Butoxycarbonylamino-methyl)-thiobenzimidic acid methyl ester

Base Information

• Chemical Name: 4-(tert-Butoxycarbonylamino-methyl)-thiobenzimidic acid methyl ester
• CAS No.: 217313-81-0
• Molecular Formula: C₁₄H₂₀N₂O₂S
• Molecular Weight: 280.391
• Mol file: 217313-81-0.mol

Synonyms:4-(tert-Butoxycarbonylamino-methyl)-thiobenzimidic acid methyl ester

Chemical Property of 4-(tert-Butoxycarbonylamino-methyl)-thiobenzimidic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(tert-Butoxycarbonylamino-methyl)-thiobenzimidic acid methyl ester

There total 5 articles about 4-(tert-Butoxycarbonylamino-methyl)-thiobenzimidic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

iminodicarboxylic acid di-tert-butyl ester (51779-32-9) → 4-(tert-Butoxycarbonylamino-methyl)-thiobenzimidic acid methyl ester (217313-81-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / NaH / tetrahydrofuran / 18 h / Ambient temperature

2: 93 percent / NaOH / tetrahydrofuran; methanol

3: H₂S, Et₃N / pyridine

4: acetone / 2 h / Heating

With sodium hydroxide; hydrogen sulfide; sodium hydride; triethylamine; In tetrahydrofuran; pyridine; methanol; acetone;

DOI:10.1080/00397919808004477

Reference yield:

tert-butyl N-[(4-cyanophenyl)methyl]carbamate (66389-80-8) → 4-(tert-Butoxycarbonylamino-methyl)-thiobenzimidic acid methyl ester (217313-81-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂S, Et₃N / pyridine

2: acetone / 2 h / Heating

With hydrogen sulfide; triethylamine; In pyridine; acetone;

DOI:10.1080/00397919808004477

Reference yield:

4-cyanobenzyl bromide (17201-43-3) → 4-(tert-Butoxycarbonylamino-methyl)-thiobenzimidic acid methyl ester (217313-81-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / NaH / tetrahydrofuran / 18 h / Ambient temperature

2: 93 percent / NaOH / tetrahydrofuran; methanol

3: H₂S, Et₃N / pyridine

4: acetone / 2 h / Heating

With sodium hydroxide; hydrogen sulfide; sodium hydride; triethylamine; In tetrahydrofuran; pyridine; methanol; acetone;

DOI:10.1080/00397919808004477

upstream raw materials:

(4-thiocarbamoyl-benzyl)-carbamic acid tert-butyl ester

methyl iodide

iminodicarboxylic acid di-tert-butyl ester

tert-butyl N-[(4-cyanophenyl)methyl]carbamate

Downstream raw materials:

[(4-aminomethyl-phenyl)-imino-methyl]-carbamic acid benzyl ester dihydrochloride

melagatran

benzyl ((4-(((tert-butoxycarbonyl)amino)methyl)phenyl)(imino)methyl)carbamate

N-Boc-4-aminomethyl benzamidine

Refernces