Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}-2-methylpropanoate

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Chemical Name:Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}-2-methylpropanoate
CAS No.:1310698-69-1
Molecular Formula:C₃₁H₃₈ClN₅O₅
Molecular Weight:596.126
Hs Code.:

Synonyms:Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}-2-methylpropanoate

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Chemical Property of Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}-2-methylpropanoate

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Technology Process of Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}-2-methylpropanoate

There total 10 articles about Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1310698-68-0
Ethyl 2-[3-({3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propylamino}methyl)phenoxy]-2-methylpropanoate

: 79-04-9
chloroacetyl chloride

: 1310698-69-1
Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}-2-methylpropanoate

Guidance literature:: In chloroform; at 0 ℃; for 0.333333h;

Reference yield:

: 50332-66-6
3-nitro-quinolin-4-ol

: 1310698-69-1
Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 9 steps

1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 2.5 h / Reflux

2: triethylamine / dichloromethane / 0 °C

3: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 5 - 23 °C

4: hydrogenchloride; benzotriazol-1-ol / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C / Inert atmosphere

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 - 20 °C

6: ammonium hydroxide; p-toluenesulfonyl chloride / dichloromethane / 0 - 20 °C

7: hydrogenchloride / water; methanol / 1 h / 50 °C

8: sodium cyanoborohydride; acetic acid / methanol / 26 h / 20 °C

9: chloroform / 0.33 h / 0 °C

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; thionyl chloride; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; triethylamine; N,N-dimethyl-formamide; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; nickel(II) chloride hexahydrate; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform; water;

Reference yield:

: 39061-97-7
4-chloro-3-nitroquinoline

: 1310698-69-1
Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / dichloromethane / 0 °C

2: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 5 - 23 °C

3: hydrogenchloride; benzotriazol-1-ol / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C / Inert atmosphere

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 - 20 °C

5: ammonium hydroxide; p-toluenesulfonyl chloride / dichloromethane / 0 - 20 °C

6: hydrogenchloride / water; methanol / 1 h / 50 °C

7: sodium cyanoborohydride; acetic acid / methanol / 26 h / 20 °C

8: chloroform / 0.33 h / 0 °C

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; triethylamine; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; nickel(II) chloride hexahydrate; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform; water;